Liposomal Antibiotic for Improved Treatment of Respiratory Infection

This PhD opportunity at Queen’s University Belfast, School of Pharmacy, focuses on the development of liposomal antibiotics for improved treatment of respiratory infections, particularly in the context of antimicrobial resistance (AMR). AMR is a major global health threat, leading to increased mortality, longer hospital stays, and higher healthcare costs. Chronic respiratory diseases such as Cystic Fibrosis (CF) and COPD are characterized by persistent lung infections with diverse bacterial communities, where current inhaled antibiotic therapies face challenges in penetrating sputum and effectively targeting pathogens. The research group has developed advanced powder formulations suitable for pulmonary delivery, demonstrating that several antibiotics used in chronic lung infection can be successfully encapsulated. The project aims to evaluate the activity of nanoparticle-encapsulated antibiotics using both planktonic and biofilm models of infection, with formulation studies to optimize antimicrobial efficacy. The work is aligned with ongoing research in the group and is expected to contribute to significant publications, highlighting the potential of liposomal delivery to enhance antibiotic effectiveness in respiratory disease management. Extensive training will be provided in nanoparticle manufacture, physicochemical characterization, and microbiological assessment of antibiotic products, including thermal stability and activity. The program emphasizes the development of planning, experimental design, numeracy, statistical, and teamwork skills. Candidates will join internationally renowned research teams and benefit from a collaborative, supportive environment. Applicants should hold an MPharm or BSc Hons degree in Pharmaceutical Sciences, Pharmaceutical Biotechnology, Biochemistry, Microbiology, Chemistry, Engineering, or a related discipline. Desirable skills include experience in pharmaceutical formulation and protein purification. Successful candidates will be motivated, quick learners, and effective communicators, with a strong, tailored CV and application. Applications are accepted year-round. Prospective students should apply via the Queen’s University Belfast Direct Applications Portal and consult the School of Pharmacy’s postgraduate research pages for further information. This project offers a unique opportunity to contribute to the fight against AMR and advance the field of drug delivery for respiratory infections.