Genomic Instability and Mutation During Inflammation-Induced Initiation of Cholangiocarcinoma

This PhD project investigates the mechanisms of genomic instability and mutation during the inflammation-induced initiation of cholangiocarcinoma, a form of bile duct cancer. Hosted at the University of Leicester within the Department of Genetics, Genomics and Cancer Sciences, the research will be supervised by Dr. E Jarman and Professor Sheela Jayaraman (University of Nottingham). The project integrates cutting-edge approaches in bioinformatics, cancer biology, cell biology, molecular biology, and molecular genetics to understand how chronic inflammation contributes to cancer development at the genomic level. Students will have the opportunity to work in a multidisciplinary environment, collaborating with experts in translational medical sciences and cancer science. The research aims to identify key genetic and molecular changes that drive the early stages of cholangiocarcinoma, with potential implications for diagnosis and therapeutic intervention. Techniques may include genomic sequencing, computational analysis, cell culture, and molecular assays. Applicants should have a strong background in biology, genetics, or biomedical sciences, with an interest in cancer research and bioinformatics. Experience in molecular biology or related laboratory techniques is advantageous but not essential. The position does not currently specify funding availability; candidates are encouraged to check the project link for updates or contact the supervisors for further details. The application deadline is 9 January 2026. Prospective students should prepare a CV, academic transcripts, and a personal statement, and submit their application via the provided project link. This is an excellent opportunity for motivated individuals seeking to advance their expertise in cancer genomics and translational research within a leading UK institution.