Simone A Joosten at Leiden University Medical Center - Research Interests, Publications & Academic Profile

Simone A Joosten

Associate Professor

Leiden University Medical Center

Netherlands

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Research Interests

Immunology

100%

Virology

70%

Immune Response

60%

Inflammatory Biology

40%

Macrophage Biology

40%

Immunogenetics

30%

Vaccinology

30%

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Recent Grants

Grant: Close

HLA-E restricted T-cell immunity in Mycobacterium tuberculosis infection

Open Date: 2019-09-04

Close Date: 2023-08-31

Grant: Close

In depth characterization of Mtb specific HLA-E restricted human CD8+ T-cells

Open Date: 2016-06-28

Close Date: 2018-05-31

Grant: Close

91686115

Open Date: 2015-05-21

Close Date:

Grant: Close

916.86.115

Open Date: 2010-04-12

Close Date: 2010-06-25

Articles18

Daily disease severity in patients with COVID-19 admitted to the hospital: The SCODA (severity of coronavirus disease assessment) score

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2023

Airway epithelial cells mount an early response to mycobacterial infection

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2023

BCG Vaccination of Health Care Workers Does Not Reduce SARS-CoV-2 Infections nor Infection Severity or Duration: a Randomized Placebo-Controlled Trial

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2023

BCG revaccination in adults enhances pro-inflammatory markers of trained immunity along with anti-inflammatory pathways

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2023

Extensive flow cytometric immunophenotyping of human PBMC incorporating detection of chemokine receptors, cytokines and tetramers

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2023

Host–pathogen interactions in the context of tuberculosis infection and disease

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2023

Identification of circulating monocytes as producers of tuberculosis disease biomarker C1q

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2023

Host biomarker-based quantitative rapid tests for detection and treatment monitoring of tuberculosis and COVID-19.

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2022

Immune Determinants of Viral Clearance in Hospitalised COVID-19 Patients: Reduced Circulating Naïve CD4+ T Cell Counts Correspond with Delayed Viral Clearance

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2022

Lung epithelial cells interact with immune cells and bacteria to shape the microenvironment in tuberculosis

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2022

Identification of HLA-E Binding Mycobacterium tuberculosis–Derived Epitopes through Improved Prediction Models

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2022

Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults.

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2022

Thermal-exchange HLA-E multimers reveal specificity in HLA-E and NKG2A/CD94 complex interactions.

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2022

Biomarkers to identify <i>Mycobacterium tuberculosis</i>-infection among borderline QuantiFERON results.

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2022

An imaging mass cytometry immunophenotyping panel for non-human primate tissues

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2022

Antigen presentation by MHC-E: a putative target for vaccination?

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2022

Applying the FAIR principles to data in a hospital: challenges and opportunities in a pandemic

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2022

Effects of BCG vaccination on donor unrestricted T cells in two prospective cohort studies

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Year:

2022

Collaborators12

Annemieke Geluk

Professor Immunodiagnostic of Mycobacterial Diseases

Leiden University Medical Center

NETHERLANDS

Cornelis Hokke

Professor

Leiden University Medical Center

NETHERLANDS

Andrew White

UNITED KINGDOM

Jacques J.M. van Dongen

Universidad de Salamanca

SPAIN

Tom H. M. Ottenhoff

Leiden University Medical Center

NETHERLANDS

Marjolein Kikkert

associate professor

Leiden University Medical Center

NETHERLANDS

Leendert Trouw

Professor

Leiden University Medical Center

NETHERLANDS

Jutte J.C. de Vries

Associate Professor (Clinical Virology)

Leiden University Medical Center

NETHERLANDS

Frank Staal

professor

Leiden University Medical Center

NETHERLANDS

Annapurna Vyakarnam

Professor

King’s College London

UNITED KINGDOM

Ferenc Scheeren

Leiden University Medical Center

NETHERLANDS

Pieter Hiemstra

Professor of Respiratory cell Biology and Immunology

Leiden University Medical Center

NETHERLANDS

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