This PhD project at the University of Bath, supervised by Professor Simon Lewis and Dr James Taylor, offers an exciting opportunity to develop new synthetic methodology in the field of radical chemistry. The research focuses on the synthesis of sulfonium salts capable of forming electron donor-acceptor (EDA) complexes, which, upon visible light irradiation, generate synthetically useful radical intermediates. These radicals will be harnessed for late-stage functionalisation of complex molecules, including the synthesis of drug substance analogues, demonstrating the practical utility of the developed reactions.

The project will explore the preparation of sulfonium salts using electrosynthesis, interrupted Pummerer reactions, and nucleophilic substitution, tailored to the desired functional groups. The anticipated outcome is the creation of stable, crystalline sulfonium salts with potential for commercial reagent development. The research is rooted in organic chemistry methodology, providing comprehensive training in practical organic synthesis, with a particular emphasis on electrosynthesis and photochemistry. Students will gain hands-on experience with advanced compound characterisation techniques such as NMR, x-ray crystallography, EPR, HRMS, IR, and UV/Vis spectroscopy, as well as mechanistic investigations and structural elucidation.

The successful candidate will join a collaborative and supportive research environment, benefiting from joint supervision and access to departmental seminars, weekly problem sessions, and opportunities to attend relevant conferences. The University of Bath values diversity and inclusivity, encouraging applications from under-represented groups and offering support for candidates with unique circumstances affecting their educational attainment.

Funding is available through the University of Bath URSA studentship competition, covering tuition fees, a generous stipend (£20,780 per annum for 2025/6), and a training support budget for 3.5 years. The studentship is open to both Home and exceptional International students, though international applicants should note that relocation, visa, and healthcare surcharge costs are not covered.

Applicants should hold, or expect to obtain, a First Class or high Upper Second Class UK Honours degree (or equivalent) in Chemistry or a closely related discipline. A master’s qualification is advantageous. Non-UK applicants must meet the English language requirements by the application deadline. Interested candidates are encouraged to contact Professor Simon Lewis for informal enquiries and to apply early, as the position may close before the advertised deadline if a suitable candidate is found.

To apply, submit a formal application via the University of Bath’s online PhD application form, selecting 'University of Bath URSA' in the funding section and quoting the project title and lead supervisor’s name. For further details, refer to the official project page and relevant references provided.