J.G.C. van Hasselt

Associate professor

Leiden University

Netherlands

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Research Interests

Pharmacology

80%

Pharmacotherapy

60%

Pharmacokinetic

70%

Antibiotic Therapy

30%

Drug Transport

30%

Cerebrovascular Physiology

30%

Blood-brain Barrier

30%

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Recent Grants

Grant: Close

Collateral sensitivity-based antibiotic dose regimens to treat resistant bacterial infections

Open Date: 2019-03-01

Close Date: 2020-10-01

Grant: Close

Metabolomic fingerprint biomarkers to guide antibiotic therapy and reduce resistance development

Open Date: 2017-05-01

Close Date: 2021-05-01

Grant: Close

CARDIOTOX

Open Date: 2015-12-01

Close Date: 2018-11-01

Articles18

Longitudinal metabolite profiling of Streptococcus pneumoniae-associated community-acquired pneumonia

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Year:

2024

Interplay of virulence factors shapes ecology and treatment outcomes in polymicrobial infections

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Year:

2024

Non‐linear blood–brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix

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Year:

2024

Pharmacokinetic/pharmacodynamic model-based optimization of temocillin dosing strategies for the treatment of systemic infections

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Year:

2024

Quantitative modeling of tumor dynamics and development of drug resistance in non‐small cell lung cancer patients treated with erlotinib

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Year:

2024

Virtual Patient Simulation Using Copula Modeling

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Year:

2024

Model‐based dose optimization framework for bedaquiline, pretomanid and linezolid for the treatment of drug‐resistant tuberculosis

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Year:

2024

Differential metabolic host response to pathogens associated with community-acquired pneumonia

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Year:

2023

Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?

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Year:

2023

Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?

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Year:

2023

Evaluation of a Cardiovascular Systems Model for Design and Analysis of Hemodynamic Safety Studies

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Year:

2023

Evaluation of a Cardiovascular Systems Model for Design and Analysis of Hemodynamic Safety Studies

Article Link

Year:

2023

Does nonlinear blood-brain barrier transport matter for morphine dosing strategies?

Article Link

Year:

2023

Attainment of Target Antibiotic Levels by Oral Treatment of Left-sided Infective Endocarditis: A POET Substudy

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Year:

2023

Predictions of Bedaquiline and Pretomanid Target Attainment in Lung Lesions of Tuberculosis Patients using Translational Minimal Physiologically Based Pharmacokinetic Modeling

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Year:

2023

Rifampicin reduces plasma concentration of linezolid in patients with infective endocarditis

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Year:

2023

Modelling inflammatory biomarker dynamics in a human lipopolysaccharide (LPS) challenge study using delay differential equations

Article Link

Year:

2022

Physiologically Based Modelling Framework for Prediction of Pulmonary Pharmacokinetics of Antimicrobial Target Site Concentrations

Article Link

Year:

2022

Collaborators6

elizabeth de lange

Professor in Predictive Pharmacology

NETHERLANDS

Thomas Hankemeier

Leiden University

NETHERLANDS

Elke Krekels

Assistant Professor

Leiden University

NETHERLANDS

Henning Bundgaard

Professor, senior consultant in cardiology

Copenhagen University Hospital

DENMARK

Henk-Jan Guchelaar

Leiden University Medical Center

NETHERLANDS

Laura Bertien Zwep

Assistant professor Statistics and Pharmacometrics

Leiden University

NETHERLANDS

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