A Next-Generation 3D Skin Model for Insights into Healthy Aging University of Hull in United Kingdom

This PhD project offers an exciting opportunity to work at the forefront of bioengineering and cellular biology, focusing on the creation of a cutting-edge 3D bioengineered human skin model. You will join a large interdisciplinary team of researchers within the University of Hull’s recently awarded £16M Centre for Translational Wound Research. The project aims to develop a multi-layered skin substitute with integrated vasculature to better understand skin resilience, mechanical strength, and the biological processes involved in aging.

You will utilize advanced 3D bioprinting technology to fabricate the skin model, incorporating key cell types such as fibroblasts and endothelial cells to create functional blood vessels within the construct. The project will involve testing the mechanical properties of the printed skin models, exploring different material compositions to optimize skin strength and durability. Additionally, you will investigate the effects of aging on skin cells, examining how interventions could enhance or weaken skin resilience.

This interdisciplinary project is ideal for candidates with a background in cell biology, biomedical sciences, or bioengineering, and an interest in tissue engineering, regenerative medicine, or aging research. You will gain hands-on experience with state-of-the-art 3D bioprinting and tissue culture techniques, as well as access to a dynamic research environment.

This project is part of the Yorkshire Bioscience Doctoral Training Partnership (YBDTP), which supports interdisciplinary research aimed at addressing key bioscience and biotechnology challenges. The successful candidate will be part of a collaborative and supportive research community based at Castle Hill Hospital, working alongside experts in skin biology, aging, and bioprinting.

If you’re passionate about contributing to innovative solutions in healthcare, this project offers the ideal opportunity for you to make a meaningful impact.