Doctoral position (100%) in Natural Product Biosynthesis & Bioengineering University of Basel in Switzerland

The University of Basel's Department of Pharmaceutical Sciences is a leading Academic Drug Discovery & Development Center, offering comprehensive coverage of academic drug research from pre-clinical to clinical phases. Within this department, the Pharmaceutical Biology Group is seeking two PhD students to join the research group of Professor Robin Teufel. The group specializes in elucidating natural product biosynthetic pathways and the underlying enzymology, with a focus on bacterial aromatic polyketide natural products that possess antibiotic and anticancer properties.

As a doctoral researcher, you will explore the biosynthesis of these natural products, characterize the involved enzymes, and engineer them to produce derivatives as potential lead compounds. This work is conducted in collaboration with project partners who focus on synthetic approaches to these compounds. The research aims to provide insights into the complex catalytic mechanisms of key biosynthetic enzymes, contributing to a fundamental understanding of natural product structural diversification.

The position is based at the Pharmacenter in Basel, Switzerland, a global hub for pharmaceutical research. You will join a dynamic, multidisciplinary team of pharmacists, chemists, and biologists working on the isolation and characterization of natural products and their biosynthesis. The University of Basel offers a vibrant scientific community, excellent opportunities for internal and external collaborations, and access to state-of-the-art instrumentation and infrastructure.

Applicants must hold a master's degree in pharmaceutical biology, (bio)chemistry, enzymology, structural biology, or microbiology. Experience and interest in natural product research and enzymology are required. Additional knowledge in molecular biology, structural biology/X-ray crystallography, protein design, natural product analysis (LCMS, NMR), microbial genetics, and/or bioinformatics is advantageous. Fluency in English at C2 level is mandatory. As a doctoral researcher, you will also assist master students and participate in teaching activities.

The position offers a generous salary and supportive mentoring, ensuring a high quality of life during your PhD studies in Switzerland. To apply, submit your application online via the official portal, including a brief cover letter, CV, and contact details of two referees. Applications sent by email, postal services, or agencies will not be considered. For general inquiries, contact Prof. Robin Teufel at [email protected]. Further information about the supervisor can be found at this academic profile page.

Application deadline: 14 May 2026.