Establishing the Impact of Cellular and Tissue Context on Malignant Transformation Cancer Research UK Manchester Institute in United Kingdom

This PhD project at the Cancer Research UK Manchester Institute investigates how cellular and tissue context influences malignant transformation, focusing on the phenomenon where identical genetic alterations drive tumorigenesis only in specific tissues. The research leverages hereditary cancer predisposition syndromes, such as von Hippel–Lindau (VHL) disease, to understand why pathogenic mutations present in every cell result in tumours only in select tissues like clear cell renal cell carcinoma, hemangioblastomas, and pheochromocytoma.

The project aims to answer fundamental questions in cancer biology: Why do the same genetic mutations cause cancer only in certain tissues? What roles do cellular and tissue environments play in permitting or restricting malignant transformation? Can dissecting genotype–phenotype relationships reveal tissue-specific vulnerabilities for early cancer interception?

Methodologically, the research group employs patient-derived induced pluripotent stem cells (iPSCs) to generate disease-relevant tissue lineages in vitro, providing a unique pre-clinical model system. The lab combines deep phenotyping of patient samples, pre-clinical modelling (including organoids, tissue fragments, and iPSCs), genome engineering, functional experiments, multi-omics data analysis, and mathematical simulations. Both wet lab and dry lab projects are feasible, and the exact project will be tailored to the candidate’s interests and aptitude.

Applicants should have a strong background or interest in cancer biology, tumour evolution, tumour microenvironment, and/or functional genomics. Experience with laboratory techniques, data analysis, or mathematical modelling is advantageous. Entry requirements include a relevant undergraduate or master's degree in biological sciences, genetics, or a related field, and English language proficiency as per University of Manchester standards.

The research group is led by Dr Samra Turajlić (Cancer Dynamics). The position is based at the Cancer Research UK Manchester Institute, with entry in September 2026. The application deadline is April 6, 2026. Funding details are not specified in the post.

To apply, submit your application online via the FindAPhD project link. Prepare your CV, academic transcripts, and a personal statement outlining your research interests. Contact the research group for specific project questions. Ensure your application is submitted before the deadline.

Relevant references include reviews and recent research on VHL disease, iPSC models, and tissue-specific oncogenesis. For further information, see the project link and referenced publications.