Funded PhD: Understanding and Controlling the Interaction Between Ocular Disease and Immune Responses to Gene Therapy University of Bristol in United Kingdom

This fully funded PhD project at the University of Bristol, in partnership with the University of Oxford and University College London, investigates the complex interplay between ocular disease and immune responses to gene therapy. Gene therapy is revolutionizing the treatment of sight-threatening conditions, with adeno-associated viral (AAV) vectors delivering therapeutic genes to the retina. However, immune responses to AAV can cause harmful inflammation, limiting the long-term safety and efficacy of these treatments. This project aims to understand and control these immune responses, particularly gene therapy-associated uveitis (GTAU), by characterizing disease-specific ocular environments and developing tailored immunomodulatory strategies.

The research will use preclinical models to study how different disease backgrounds, such as diabetes or retinal degeneration, influence immune responses to AAV. The student will identify which immune cells persist in the eye after treatment, map their locations, and analyze gene expression changes in ocular tissues. The project also evaluates immunomodulatory compounds to mitigate harmful inflammation, with the goal of improving clinical outcomes and supporting the safe expansion of gene therapy for eye diseases.

Supervision is provided by Dr Dave Copland (University of Bristol) and Associate Professor Kanmin Xue (University of Oxford), with additional training from Dr Colin Chu (UCL). The student will be based primarily at Bristol, receiving hands-on training in ocular disease models, flow cytometry, and advanced imaging, as well as formal bioinformatics training at Oxford. The collaborative environment includes opportunities to attend international conferences and participate in a vibrant Vision Research Network.

The studentship is open to UK and international applicants and is funded by the Fight For Sight UK Vision Research Network Doctoral Training Programme. It covers a four-year duration, with an annual stipend at the UKRI rate (£19,237), full tuition fees, and research costs. Overseas students must cover the difference between overseas and UK fees and any relocation or visa costs. Applicants should have a background in biomedical sciences, immunology, neuroscience, or related fields. Prior experience in flow cytometry, confocal microscopy, or animal models is helpful but not required, as full training is provided. Curiosity, resilience, and enthusiasm for translational science are essential.

To apply, submit your application via the University of Bristol portal, selecting ‘Cellular and Molecular Medicine (PhD)’ for a September 2026 start. Please check the programme entry requirements before applying. For informal enquiries, contact Dr Dave Copland at [email protected].