Location, location, location: DNA damage sensors which launch protective responses to DNA damage University of Dundee in United Kingdom

DNA damage happens at very high frequency in the cells in our bodies – meaning that the instructions for the proper functioning of cells could be altered unless the mistakes are spotted and corrected. We recently started a search for new surveillance factors in human cells that can detect damaged DNA and help to launch the DDR “DNA damage response” that stops secondary consequences of DNA damage such as mutations, disease or cell death (see for example EMBO Journal 40, e108271). Specifically, we screened for factors in cells capable of recognizing damaged DNA inside the nucleus, which we induce experimentally using lasers attached to a confocal microscope. These experiments revealed a range of enzymes that rapidly translocate to damaged DNA, suggesting participation in cellular responses to DNA damage. These enzymes include nucleases, DUBs and helicases. We now wish to understand in detail how these factors recognize damaged DNA and how they participate in DNA repair and other protective responses.

At the MRC PPU, as well as the possibility of a PhD in one particular lab, we offer the possibility of two 4.5-month rotations in labs of their choice. A range of other projects from MRC PPU scientists are advertised here . Rotations provide valuable experience and help with deciding on the choice of PhD project and research group.

To apply for this project, or any of our other PhD projects, please complete the following application

APPLY NOW

When completing the application, there will be space to copy over your CV, contact details of three referees and a cover letter explaining why you have chosen to apply to MRC PPU.

The closing date for applications is 15th January 2025. Applications from overseas students are welcome.

If you have any questions or need to get in touch with us, please email us at [email protected] .