Phage-Based Diagnostics for Johne’s Disease University of Calgary in Canada

Project Overview
Johne’s disease is a major infectious disease affecting cattle and small ruminants, with significant economic and animal health impacts. Current diagnostic methods are slow, costly, and lack sensitivity for early or subclinical detection. The De Buck Laboratory at the University of Calgary is recruiting a motivated MSc or PhD student to join a cutting-edge research program focused on developing a next-generation, phage-based diagnostic platform for Johne’s disease. This innovative project leverages mycobacteriophages and genetic engineering to create a rapid, highly sensitive, PCR-free diagnostic tool designed for on-farm use, aiming to enable earlier detection and improved disease control.

Research Environment
The De Buck Lab is internationally recognized for its two decades of pioneering research on Johne’s disease, including bacterial pathogenesis, host–pathogen interactions, diagnostics, vaccines, and phage biology. The group is known for integrating fundamental microbiology with practical applications, collaborating closely with producers, veterinarians, and industry partners to ensure research outcomes have real-world impact. Students will benefit from a vibrant research community within the Faculty of Veterinary Medicine and the broader University of Calgary environment.

Funding and Training
Competitive graduate funding is available for both MSc and PhD students. The program offers comprehensive research training, professional development opportunities, and access to a dynamic academic and social environment in Calgary, a city renowned for its outdoor recreation and quality of life.

Eligibility and Requirements
Candidates must have a BSc (for MSc) or MSc (for PhD) in Microbiology, Molecular Biology, Veterinary Sciences, Biotechnology, or a related field. Essential skills include hands-on experience with molecular biology techniques (such as cloning, PCR-based methods, and bacterial genetics) and solid microbiology skills, ideally with experience working with bacterial pathogens. The ability to work independently and collaboratively is required. Highly desirable qualifications include experience with mycobacteria, bacteriophages, or genetic engineering, familiarity with CRISPR-based approaches, interest in diagnostics development, and motivation to participate in field validation studies and engage with producers.

Application Process
Interested applicants should submit a cover letter outlining research interests, relevant experience, and the intended degree (MSc or PhD), a CV detailing technical skills and research experience, and contact information for 2–3 references. Applications should be sent to Dr. Jeroen De Buck at [email protected]. Applications are reviewed on a rolling basis until the position is filled. For more details, visit the project page.

Key Research Areas
Bacteriology, Biochemistry, Biotechnology, Genetic Engineering, Molecular Biology, Bioengineering.

Deadline
Applications are accepted until January 31, 2026.