PhD in Molecular Upconversion Luminescence via [d-f] Hybrids for Bioimaging Applications University of Southampton in United Kingdom

This fully funded PhD project at the University of Southampton focuses on the development of state-of-the-art heteropolymetallic architectures—specifically organometallic transition-metal and lanthanide complexes—for two-photon molecular upconversion luminescence. The research aims to create novel bioimaging probes that address the limitations of conventional luminescent imaging, such as autofluorescence and poor tissue penetration, by leveraging upconversion (UC) processes that enable ultra-long-lifetime phosphorescence within the biological window.

As a student, you will synthesize and characterize molecular and supramolecular [d-f] heteropolynuclear assemblies, utilizing coordination and organometallic d-metal complexes (including RuII, IrIII, PtII) in combination with azamacrocyclic lanthanide complexes (YbIII, NdIII). The project involves multistep synthesis, rigorous photophysical characterization, and investigation of fundamental energy-transfer processes via luminescence spectroscopy. The ultimate goal is to develop unprecedented in vivo imaging platforms based on molecular upconversion.

You will gain hands-on experience in synthetic organic and organometallic chemistry, coordination chemistry, photoluminescence spectroscopy, and single-crystal X-ray crystallography. Access to state-of-the-art facilities is provided, including NMR spectroscopy, IR, HPLC, mass spectrometry, and world-leading X-ray diffraction resources. The research environment encourages participation in group meetings, school seminars, and national/international conferences, offering opportunities to disseminate your findings and network with global leaders in the field.

The University of Southampton supports professional development through the PGR Development Hub, which offers a suite of training courses and support services to enhance well-being and employability. The School of Chemistry and Chemical Engineering is committed to equality, diversity, and inclusivity, as reflected in its Athena SWAN award, and welcomes applicants from all backgrounds, including those seeking flexible working patterns or returning from career breaks.

Funding: This studentship is fully funded by the EPSRC DLA, covering tuition fees and a stipend.

Eligibility: Applicants must hold a UK 2:1 honours degree or its international equivalent in a relevant subject. Applications should include a CV, two academic references, degree transcripts and certificates, and evidence of English language proficiency if required.

Application deadline: 31 March 2026.

How to apply: Apply online for the PhD Chemistry (7189) programme (Research) for 2026/27 in the Faculty of Engineering and Physical Sciences, indicating the supervisor's name in section 2. For general queries, contact [email protected]. For project-specific questions, contact Dr Richard Knighton at [email protected].