PhD Opportunity in AI-Driven Enzyme Design for Cofactor-Dependent Reactions at TU Graz Technische Universität Graz in Austria

Technische Universität Graz is advertising a PhD opportunity in AI-driven enzyme design for cofactor-dependent reactions.

The project is hosted in the lab of Gustav Oberdorfer (Assistant Professor at TU Graz) and builds on the recently established RiffDiff computational pipeline. The research will extend this method to make it aware of (non)covalently linked cofactors across a variety of transformations, with a strong focus on protein design, biocatalysis, and enzyme engineering.

This is a frontier-pushing doctoral project funded by a doc.funds doctoral training grant from the Austrian Science Fund (FWF). The selected candidate will be embedded in the newly funded BioTechPredict PhD program at TU Graz and will have the opportunity to carry out rigorous structure-function testing using iterative design-build-test-learn cycles.

Relevant research keywords include enzyme design, computational biology, machine learning, biocatalysis, and cofactor-dependent catalysis. The post is especially suitable for candidates interested in combining computational methods with experimental validation in a modern protein engineering environment.

The post includes a direct application link to the job offer. No deadline is stated in the post excerpt provided.