PhD position: Exploiting light-matter interactions to steer enantioselective crystallization of API Université catholique de Louvain in Belgium

This PhD position at Université catholique de Louvain (UCLouvain) is part of the collaborative Belgian project 'Light, Twist, Action', which unites three research groups from UCLouvain and KULeuven. The project aims to advance fundamental understanding of enantioselective crystallization, with a special focus on light-induced processes. The research will contribute to steering and controlling preferential crystallization and deracemization, which are crucial for producing enantiopure compounds, especially active pharmaceutical ingredients (APIs).

The successful candidate will join a dynamic team of four permanent researchers and three PhD students, working closely with other groups. The project centers on developing crystallization processes, including spontaneous deracemization from solution, using nucleation studies and crystal engineering. A key aspect is the use of strong light sources as external influencers to control these processes. The research activities include studying thermodynamics and solubility data of reference systems, investigating nucleation kinetics in enantioselective crystallizing systems, developing methodologies for steering enantioselective systems (both internal and external influences), studying racemization of enantiopure compounds, and combining racemization with steering to achieve controlled deracemization. The position also involves report and article writing, as well as conference participation.

Applicants should have a Master's degree in Chemistry, Engineering, or Physics, with a strong academic record. Experience in optics is advantageous, and proficiency in English is required. Social skills are important, as the project is highly collaborative. The position is full-time and based in Louvain la Neuve, Belgium, starting September 1, 2026. The application deadline is July 31, 2026.

To apply, send your application materials (cover letter, CV, academic transcripts) to Dr Tom Leyssens at [email protected]. For more information about the research group, visit the group website. The full position description is available on Euraxess.

This opportunity is ideal for candidates interested in physical chemistry, chemical engineering, applied physics, and process development, especially those keen to explore light-matter interactions and crystallization mechanisms in a collaborative academic environment.