PhD Position in Biodistribution and Blood Brain Barrier Transport – Protein Biology, Karolinska Institutet Karolinska Institutet in Sweden

Karolinska Institutet is offering a fully funded PhD position focused on the biodistribution and transport of a biological drug candidate across the blood brain barrier. The research aims to understand how the BRICHOS domain, a molecular chaperone, can access the brain and reduce Alzheimer’s disease pathology, with potential for therapeutic applications. The project involves in vivo pharmacokinetic and biodistribution studies in mice, as well as investigations into the molecular and cellular mechanisms of brain delivery.

The research group is multidisciplinary, with expertise ranging from biophysics to clinical pharmacology, and offers a collaborative environment with access to advanced preclinical and translational resources. The student will be based at the Departments of Medicine Huddinge and Laboratory Medicine, Karolinska Institutet, Sweden.

Applicants must hold a Master’s degree in a relevant life science field or equivalent, with a strong background in protein biology and cellular mechanisms. Experience with quantitative data analysis, in vitro experimental work, and proficiency in English are required. Desirable skills include experience with rodent models, protein production, drug disposition, and familiarity with brain anatomy. Creativity, independence, and a strong interest in experimental biomedical research are highly valued.

The position is a full-time doctoral studentship for up to four years, with a contractual salary and additional benefits such as access to a modern gym and medical care reimbursements. The application deadline is 01 March 2026. Applications should be submitted via the Varbi recruitment system, including a personal letter, CV, degree projects, publications, and documents certifying eligibility. For more information, contact Professor Janne Johansson at Karolinska Institutet.

Keywords: biodistribution, blood brain barrier, protein biology, cellular mechanisms, pharmacokinetics, Alzheimer’s disease, biomedical research.