PhD Position in Molecular Exercise Physiology and Muscle Hypertrophy Mechanisms University of Copenhagen in Denmark

The University of Copenhagen is offering a PhD fellowship in Molecular Exercise Physiology, focusing on the mechanisms of skeletal muscle hypertrophy. The position is based in the Department of Nutrition, Exercise and Sports (NEXS) and supervised by Professor Thomas E. Jensen. The research project aims to systematically dissect load-dependent and load-independent pathways regulating muscle hypertrophy, utilizing cutting-edge in vivo and in vitro models, including CRISPR/Cas9 gene editing and advanced imaging techniques.

Loss of muscle mass is a major contributor to frailty and morbidity in aging and disease. Resistance exercise remains the only effective countermeasure against muscle wasting, yet the molecular mechanisms triggering hypertrophy are not fully understood. This project will challenge the notion that muscle growth depends solely on mechanical load, highlighting the roles of load-independent neuroendocrine and paracrine factors.

The PhD student will employ a novel voluntary mouse resistance exercise model, CRISPR/Cas9 multiplexed gene editing, human skeletal muscle in vitro models, and advanced biochemistry. The project is collaborative, involving national and international partners such as Steno Diabetes Center Aarhus, University of Southern Denmark, DTU, and the University of Birmingham.

Responsibilities include carrying out independent research, completing PhD courses (approx. 30 ECTS / ½ FTE), and participating in conferences and workshops, including a research stay at another institution. Applicants should have a strong background in molecular biology, physiology, or related fields, and experience with CRISPR/Cas9, muscle cell signaling, biochemistry, or advanced imaging is highly desirable.

The fellowship is funded by the Independent Research Fund Denmark (DFF) and covers tuition, stipend, and research activities for three years. The application deadline is January 29, 2026, with the expected start date of June 1, 2026. Interested candidates should apply online and contact Professor Thomas E. Jensen for further information.