PhD position in MSCA doctoral network iSTRIDE: In vivo analysis and diagnostic profiling of biofilm-associated medical device infections University Hospital Regensburg in Germany

The University Hospital Regensburg, Laboratory for Experimental Trauma Surgery, offers a fully funded PhD position within the Marie Sklodowska-Curie Doctoral Networks (MSCA-DN) project iSTRIDE. This international doctoral network brings together leading academic and industrial partners to address the pathology and prevention of indwelling device-associated infections (IDAls). The iSTRIDE consortium includes six hospitals, one research institute, seven academic universities, and two industrial partners, providing a rich environment for interdisciplinary research and training.

The PhD project focuses on in vivo analysis and diagnostic profiling of biofilm-associated medical device infections. Biofilm-associated infections pose significant clinical challenges due to their resistance to antimicrobial therapies and complex polymicrobial nature. The research aims to investigate microbial colonization and biofilm formation on medical devices, emphasizing in vivo dynamics and advanced diagnostic approaches. Preclinical infection models will be used alongside longitudinal analysis of microbial communities at the device-tissue interface. The project will explore polymicrobial interactions, host inflammatory responses, and early stages of device-associated infection development using molecular and imaging-based techniques.

In collaboration with lnBiome (Dr. Dries Budding), the project will validate rapid, culture-independent diagnostic strategies for detecting and monitoring device-associated infections. By integrating in vivo models with translational diagnostic approaches, the research aims to improve early detection and understanding of medical device infections, supporting the development of more effective prevention and treatment strategies. International secondments are included, focusing on clinical exposure, advanced imaging (FISH), and bioinformatics.

The iSTRIDE Doctoral Network provides advanced training for 10 doctoral candidates, emphasizing translational skills for careers in biomedical research and medical technology innovation. Training is delivered through cross-institutional collaboration, industry engagement, structured workshops, and research secondments. All doctoral candidates will complete a hospital internship during their first year, gaining early exposure to clinical environments and real-world healthcare challenges.

Applicants should have a strong interest in microbiology, infection biology, and medical device-associated infections. A Master's degree in biology, microbiology, biomedical sciences, molecular medicine, or a related field is required. Experience with microbial culture techniques, molecular biology, and/or microscopy is highly desirable. Prior exposure to animal models, biofilm research, or microbial community analysis is an advantage but not mandatory. Candidates must demonstrate independence, analytical skills, organization, proactive attitude, and strong problem-solving abilities. Excellent communication skills in English are essential, and candidates should be able to work both independently and as part of an interdisciplinary team.

Eligibility requirements include compliance with the mobility rules of the Marie Sklodowska-Curie Actions: applicants must not have resided or carried out their main activity in Germany for more than 12 months during the past 3 years prior to recruitment and must not already possess a doctoral degree. Disabled persons will be given preferential consideration if equally qualified.

The appointment is for a maximum of 36 months (PhD position), full-time, and includes an attractive salary and allowances package in accordance with MSCA regulations. The Laboratory of Experimental Trauma Surgery offers a stimulating, supportive, and international environment for scientific and professional development.

To apply, submit your application via the online portal by 22 May 2026, including a motivation letter, CV, and contact information for references. All documents must be in English. For further information, contact [email protected].