PhD Position in Organic and Peptide Chemistry for Antimicrobial Peptide Analogue Development University of Montpellier in France

This PhD position at the University of Montpellier is part of the ANR Alterin research project, focused on developing new peptide analogues to combat antimicrobial resistance. The project is a collaboration between the University of Brest, Institut Charles Gerhardt Montpellier (ICGM), and Institut des Biomolécules Max Mousseron (IBMM), involving supervisors JM Campagne, R de Figueiredo, P Verdié, G Subra, C Echalier, and Y Fleury. The research centers on alterins, a family of antibacterial peptides from marine bacteria, highly active against Gram-negative bacteria. These cyclolipopeptides feature a heptapeptide cycle, hydrocarbon tail, and several non-canonical amino acids, targeting lipopolysaccharide (LPS) for effective, low-toxicity analogs.

The PhD student will design analogues, prodrugs, and conjugates to enhance the efficiency and selectivity of alterin analogues. Key tasks include determining the absolute and relative configurations of amino acids, synthesizing non-canonical amino acid building blocks (such as β-OH Dab and dehydrobutyrine), and developing solution and solid-phase synthesis strategies. The student will prepare small libraries of analogues, exploring structure/activity relationships by varying crucial positions within the alterin structure. Strategies involving side chain anchoring and N/O Acyl shift rearrangements will be tested for efficient synthesis, with modifications to the lipidic side chain and development of prodrug analogues and depsipeptide derivatives.

Activities include organic synthesis, stereoselective synthesis of protected amino acids, chemical analysis (NMR, LC/MS, Marfey’s analysis), and solid-phase peptide synthesis. The student will utilize resources from both IBMM and ICGM teams, as well as the SynBio3 platform and UAR PAC Balard facilities. Safety training in good laboratory practices (GLP) and equipment use will be provided, including safe handling of chemical and biological products and waste management according to regulations.

The position offers a gross monthly salary of €2,300 for a 3-year contract, starting 1 October 2026. Applicants must have a Master’s degree in Organic Chemistry, with skills in biomolecule synthesis and analysis. Basic knowledge in peptide chemistry, bacteriology, and biology is appreciated. Candidates should demonstrate teamwork, rigor, organization, scientific English writing and reporting skills, autonomy, and initiative. Applications must include a CV and cover letter, submitted via the online portal before 20 May 2026.

This opportunity is ideal for candidates interested in advanced peptide chemistry, antimicrobial research, and interdisciplinary collaboration. The project provides access to state-of-the-art facilities and expert supervision, with a focus on innovative approaches to peptide analogue development and bioassays. For more information and to apply, visit the University of Montpellier recruitment portal.