PhD Position – Intestinal MAdCAM-1 Assessment for Prognostic and Improvement of Functional Outcome in Stroke University of Caen Normandie in France

This PhD position at the University of Caen Normandie, hosted within the INSERM UMR-S 1237 PhIND unit and the Blood, Brain and Memory @ Caen Normandie institute (BBM@C), offers an exciting opportunity to investigate the role of intestinal MAdCAM-1 in stroke prognosis and functional recovery. The project addresses a critical gap in stroke research by exploring how intestinal inflammation and the gut-brain axis influence outcomes after stroke, aiming to develop innovative therapeutic strategies.

The research will utilize a murine model of stroke, employing advanced immuno-MRI techniques to target specific adhesion molecules. The candidate will conduct flow cytometry and whole-genome sequencing analyses of intestinal content to assess changes in both intestinal and central immunity, as well as microbiota composition. Functional deficits and recovery post-stroke will be evaluated using functional ultrasound imaging and behavioral tests. The project also extends to human studies, examining intestinal inflammation and gut microbiota in patients in relation to neurological deficits and recovery. Two novel therapeutic strategies targeting intestinal inflammation will be tested in mice to improve functional outcomes.

The host laboratory, led by Professor Denis Vivien, is internationally recognized for its expertise in stroke research and imaging innovation. Located at the Cyceron center in Caen, the lab provides access to state-of-the-art imaging technologies, including 7T MRI and PET systems for small animals, magnetic particle imaging, intravital two-photon microscopy, and photoacoustic imaging. The center also offers core facilities in molecular and cellular biology, experimental surgery, and in vivo experimentation, as well as a large animal facility affiliated with the university. The team benefits from advanced microscopy systems, calcium imaging, spinning-disc epifluorescence microscopy, and dedicated analysis tools. Additional techniques include Doppler speckle imaging, fast ultrasound imaging, and behavioral testing platforms. The BBM@C institute provides access to sequencing platforms, human sample storage and analysis, and advanced microscopy resources.

Applicants should have a Master’s degree in neuroscience, neurobiology, or biology, along with French regulatory certifications for animal experimentation or equivalent (e.g., FELASA accreditation). A strong interest in preclinical and translational research, as well as the gut-brain axis, is essential. Proficiency in French or English is required. Training in experimental surgery and prior experience with relevant techniques (small-animal MRI, flow cytometry, genomic analyses, behavioral testing) are appreciated.

The position is full-time and temporary, starting on 1 October 2026. Funding details are not specified in the announcement. Applications should be submitted by 22 May 2026. For further information or to apply, contact [email protected] or [email protected], and review the position details at the provided Euraxess link.