PhD Positions in Time-Resolved Structural Biology and Cryo-EM – Biochemistry at Uppsala University Uppsala University in Sweden

Two PhD positions are available in the Westenhoff research group at Uppsala University, Sweden, focusing on advanced topics in biochemistry and structural biology. The group is seeking highly motivated candidates to work on (1) time-resolved crystallography and (2) time-resolved single-particle cryo electron microscopy (cryo EM). The research aims to uncover the structural dynamics of proteins and chemical reactions, with projects involving the study of photoreceptor proteins, charge transfer mechanisms, and the development of novel methods in time-resolved structural biology.

The Department of Chemistry for Life Sciences at Uppsala University offers a vibrant, international environment with over 100 staff and 45 PhD students. The department is located at the Biomedical Centre, facilitating interdisciplinary collaborations with biology, pharmacy, medicine, and SciLifeLab, and providing access to advanced experimental and theoretical infrastructure. English is the main working language.

Project 1 involves using time-resolved serial femtosecond crystallography at Free-electron laser sources to study structural changes in photoreceptor proteins such as cryptochrome and photolyase. Project 2 focuses on developing and applying time-resolved cryo EM to investigate protein structures, including receptor proteins in microalgae, ATPases, and proteins in the respiratory chain. Both projects offer significant creative freedom, resources, and the opportunity to develop new experimental and analytical methods.

Applicants should have a strong background in biochemistry, structural biology, biophysics, or related fields with a substantial chemistry component. Eligibility requires at least 240 ECTS credits (including 60 at Master’s level and an independent project), and specific coursework in biochemistry and chemistry. Excellent English proficiency, motivation, independence, and collaborative skills are essential. Teaching or outreach experience is considered an asset.

The positions are fully funded, full-time, and temporary according to Swedish Higher Education regulations. Duties include research, participation in third-cycle courses, and up to 20% teaching or departmental work. The group has a strong track record, including ERC awards and high-impact publications, and offers a stimulating, supportive environment for developing independent researchers.

Applications must be submitted through Uppsala University's recruitment system by 21 December 2025. For more information, contact Prof Sebastian Westenhoff at [email protected]. Further details and application links are provided in the announcement.