PhD project on genetic mechanisms of antimicrobial resistance and biofilm formation at the University of Otago University of Otago in New Zealand

The rise of antimicrobial resistance (AMR) in ESKAPE pathogens, particularly Pseudomonas aeruginosa , poses a significant threat to global health. As a World Health Organization "critical" priority pathogen, P. aeruginosa is notorious for its multidrug resistance, ability to form resilient biofilms, and persistence in clinical settings, leading to severe and often fatal infections. Understanding the genetic and molecular mechanisms underlying these traits is critical to developing effective strategies to combat this pathogen.

This project will focus on investigating the genetic determinants of AMR and biofilm formation in P. aeruginosa , with an emphasis on clinical isolates that exhibit recalcitrant behavior. Using cutting-edge genomic, transcriptomic, and molecular biology techniques, the project aims to:

1. Identify key genetic pathways and regulatory networks involved in biofilm formation and antimicrobial resistance.
2. Characterize the role of novel universal stress proteins in the persistence and virulence of P. aeruginosa .
3. Explore the stress response caused by environmental factors in driving resistance and biofilm-associated infections.

The findings from this research will inform the development of innovative antimicrobial strategies, including nanomedicine-based approaches, to target P. aeruginosa and other hard-to-treat pathogens. By integrating interdisciplinary methods, this project will contribute to the global effort to combat AMR and improve outcomes for patients suffering from chronic and acute infections.

We seek highly motivated candidates with an MSc degree in microbiology, genetics, molecular biology, bioinformatics or a related field. Applicants must have a strong academic record, preferably with a near-perfect GPA, and substantial research experience, as demonstrated by their MSc thesis and publications. The successful candidate will join a dynamic and collaborative research team at the Pletzer Lab, where they will have access to state-of-the-art facilities and opportunities to contribute to groundbreaking research.

If you are passionate about tackling the challenges of antimicrobial resistance and have a strong background in bacterial genetics, we encourage you to apply. Please submit a cover letter outlining your research interests, a CV with details of published work, a summary of your MSc thesis, full academic transcripts, and contact information for two to three references to [email protected] .

Join us in the vibrant city of Dunedin, New Zealand, renowned for its student culture, friendly community, and stunning natural surroundings. This is an exceptional opportunity to advance your research career while contributing to a critical global health initiative. Learn more about our lab and research at www.pletzerlab.com .