PhD Student Position in Deep Learning Modeling of Cancer Cell Mechanisms Karolinska Institutet in Sweden

This PhD position at Karolinska Institutet and SciLifeLab offers an exciting opportunity to contribute to advancing human health through cutting-edge research in cancer biology and precision medicine. The project is based in Avlant Nilsson’s research group, which focuses on developing mechanistic AI models of cancer cells by integrating large-scale multi-omics data (metabolomics, transcriptomics, proteomics) with molecular interaction networks. The central aim is to build interpretable deep learning models that capture system-level mechanisms in cancer, ultimately enabling computer-aided design of precision therapies.

The lab’s goal is to construct a unified computational model describing how molecular processes such as signaling, gene regulation, and metabolism interact to determine cellular behavior. This research is part of the SciLifeLab and DDLS (Data-Driven Life Science) program, providing access to a highly collaborative and interdisciplinary environment, as well as state-of-the-art computational infrastructure including the Berzelius supercomputer.

The main supervisor is Assistant Professor Avlant Nilsson, with Professor Randall S. Johnson as co-supervisor. The project involves developing next-generation AI models of cancer cells by integrating metabolism, signaling, and gene regulation into a single predictive framework. You will design biologically constrained deep learning models using novel architectures based on recurrent neural networks (RNNs) to capture how molecular states evolve and give rise to cellular phenotypes. Key components of the project include:

• Model development: Integrating modules of cellular subsystems to predict cellular states
• In silico target discovery: Predicting metabolic vulnerabilities and prioritizing candidates for experimental validation
• Biomarker discovery: Identifying molecular states associated with drug response across cancer contexts

You will collaborate closely with computational team members and external partners, contributing to experiment design guided by model predictions. The research environment is creative and inspiring, with opportunities for international exchanges and access to a wide range of elective courses.

Eligibility requirements include a master’s degree or equivalent, proficiency in English (English B/English 6 at Swedish upper secondary school), and strong programming skills in Python. Familiarity with version control (e.g. Git), the ability to work independently and collaboratively, and proficiency in written and spoken English are necessary. Desirable qualifications include backgrounds in physics, computational biology, machine learning, applied mathematics, experience with deep learning frameworks (PyTorch, TensorFlow), familiarity with cancer and cell biology, and experience analyzing biological or multi-omics data. Applicants from quantitative disciplines are encouraged, and prior biological expertise is not required.

The doctoral student will be employed on a full-time studentship for up to four years, receiving a contractual monthly salary. Additional benefits include free access to the university gym and medical care reimbursements. Karolinska Institutet values diversity and inclusion, fostering an environment where all individuals are empowered to contribute their unique perspectives.

To apply, submit your application and supporting documents through the Varbi recruitment system. Required documents include a personal letter, CV, degree projects, previous publications, documentation of desirable skills, and certificates of eligibility. The deadline for applications is 27 May 2026. Selection will be based on subject knowledge, analytical skill, and other relevant experience. All applicants will be informed when the recruitment is completed.

Join Karolinska Institutet and make a difference in the fight against cancer!