Postdoctoral Fellow Position in RNA Biology, Alternative Splicing, and RNA Therapeutics University of Pennsylvania in United States

Postdoctoral Fellow position available in the laboratory of Prof. Rotem Karni at the Perelman School of Medicine, University of Pennsylvania.

The lab studies RNA processing and gene expression regulation, with a strong focus on alternative splicing, RNA-binding proteins, RNA modifications, nonsense-mediated decay, and RNA-based therapeutic strategies. Research applications include cancer, metastasis, and rare genetic diseases.

The successful candidate will work on one or more of the following areas: regulation of alternative splicing by RNA-binding proteins and signaling pathways; RNA processing programs controlling cell migration, invasion, and tumor progression; RNA therapeutics such as splice-switching oligonucleotides, decoy oligonucleotides, and targeted RNA modulation; m6A-dependent regulation of RNA stability and nonsense-mediated decay; and functional genomics approaches to identify RNA-based therapeutic vulnerabilities.

This postdoctoral opening combines molecular biology, RNA biochemistry, cell biology, genomics, and disease models. The position offers opportunities to develop independent projects, publish high-impact work, present at international meetings, and receive mentorship toward an academic or industry career.

Eligibility: applicants should hold a PhD or MD/PhD in molecular biology, RNA biology, cancer biology, genetics, biochemistry, genomics, or a related field. Strong experimental skills are required; experience with RNA-seq, CRISPR screens, oligonucleotide therapeutics, cancer models, or computational analysis is advantageous.

How to apply: email a cover letter, CV, and contact information for three references to Prof. Rotem Karni at [email protected]. Review begins immediately and continues until the position is filled.