Boston Children's Hospital, in collaboration with Harvard Medical School, is offering a postdoctoral research position in the laboratory of Dr. James D McCully. The lab is renowned for its pioneering work in mitochondrial transplantation, a novel therapeutic intervention aimed at treating ischemia-reperfusion injury and advancing myocardial repair and regeneration. Research in the McCully Lab focuses on the isolation and transplantation of autogeneic mitochondria to enhance tissue recovery and function following ischemic injury, with applications extending to the heart, lungs, kidneys, and limbs.

The successful candidate will join a collaborative and well-mentored environment, contributing to innovative mechanistic studies in mitochondrial transplantation and its therapeutic applications. The research involves advanced molecular techniques, including mammalian cell culture (with an emphasis on human iPSC culture and directed differentiation), CRISPR genome editing (knockout/knockin, clone selection and validation), and in vivo small-animal work (mouse/rat handling, breeding, genotyping, tissue collection, and potentially surgical procedures). The lab's work has demonstrated that transplanted mitochondria can significantly decrease myonecrosis and enhance post-ischemic functional recovery, providing a unique immunological advantage without the need for anti-rejection drugs.

Applicants should possess a PhD in biology, biomedical sciences, or a related field, with demonstrated expertise in cell culture and molecular biology techniques. Experience with CRISPR genome editing and small-animal models is highly desirable. Strong communication skills and the ability to work both independently and as part of a team are essential.

While specific funding details are not provided, postdoctoral positions at Boston Children's Hospital typically offer competitive salaries and benefits. Interested candidates are encouraged to review the lab's research at the McCully Lab website and submit their CV to [email protected].

For more information about the lab and its research focus, visit the lab homepage or the Science Notes LinkedIn page.