Boston Children's Hospital, in collaboration with Harvard Medical School, is offering an exciting postdoctoral research opportunity in the laboratory of Dr. James McCully. The McCully Lab focuses on innovative mechanistic studies in mitochondrial transplantation and its therapeutic applications, particularly for ischemia-reperfusion injury and myocardial repair. The lab's research explores cell-based therapies, mitochondrial isolation and transplantation, and the development of novel interventions to enhance tissue recovery and function following injury.

The successful candidate will join a collaborative and well-mentored environment, contributing to projects involving mammalian cell culture (including human iPSC culture and directed differentiation), advanced molecular techniques such as CRISPR genome editing (knockout/knockin, clone selection and validation), and in vivo small-animal models (mouse/rat handling, breeding, genotyping, tissue collection, and potentially surgical procedures). The research aims to elucidate the mechanisms by which autogeneic mitochondrial transplantation can improve energy production, tissue protection, and functional recovery in various organs, including the heart, lungs, kidneys, and limbs.

Applicants should have a PhD in a relevant field (biology, biomedical sciences, or related discipline) and demonstrate expertise in cell culture, molecular biology, and animal research. Strong communication skills and the ability to work both independently and collaboratively are essential. The position offers intellectual independence and the opportunity to contribute to cutting-edge research with significant translational potential.

To apply, interested candidates should send their CV to [email protected]. For more information about the lab's research, visit the McCully Lab website. This is a paid postdoctoral position; however, specific funding details are not provided in the announcement. The application deadline is not specified, so early application is encouraged.

Keywords: mitochondrial transplantation, cell culture, molecular techniques, CRISPR genome editing, myocardial repair, ischemia-reperfusion injury, cell-based therapies, cardiac surgery, in vivo studies, mouse/rat models.