The Cancer Research Center of Marseille (CRCM) is offering a 2-year postdoctoral position in the Membrane Proteomics and Cancer (MEMPROT) team, focusing on single cell proteomics applied to breast cancer resistance. The project is funded by the French government under the France 2030 investment plan and the Initiative of Excellence of Aix-Marseille University (AMIDEX). The successful candidate will develop and apply single cell proteomics to analyze chemoresistance in breast cancer, particularly triple-negative breast cancer (TNBC), which is known for its poor prognosis and high recurrence rate. The research will involve characterizing cellular proteome heterogeneity in patient-derived xenografts (PDX) and tumor biopsies before and after resistance to commonly used chemotherapies.

The postdoctoral researcher will collaborate closely with the teams of E. Charafe and C. Ginestier at CRCM, as well as engineers from the Marseille Proteomics platform (MAP), utilizing advanced mass spectrometry equipment (Evosep Eno - Astral). The position emphasizes interdisciplinary research, integrating cancer biology, proteomics, and bioinformatics to identify new therapeutic targets and improve patient outcomes. The CRCM is a leading institution in cancer research, with extensive facilities and collaborations, and is located on the campus of Institute Paoli-Calmettes (IPC), a reference medical center for cancer treatment.

Applicants should have a PhD in cancer biology, cellular biology, or biochemistry, with experience in protein biochemistry and bioinformatics. Mass spectrometry experience is advantageous but not mandatory. The salary ranges from 2600 to 3050 euros per month gross, depending on experience, and follows the Amidex Aix Marseille university salary scale. The application deadline is March 1st, 2026. Interested candidates should submit a CV, motivation letter, and contacts of three references to [email protected].

Key research areas include breast cancer, single cell proteomics, mass spectrometry, bioinformatics, and tumor heterogeneity. The CRCM supports innovative research and training, with strong links to Aix-Marseille University and other institutes. This position offers an excellent opportunity for postdoctoral researchers to contribute to cutting-edge cancer research in a collaborative and well-resourced environment.