The European Molecular Biology Laboratory (EMBL) in Rome, Italy, is seeking a postdoctoral researcher or project co-lead to join Jamie Hackett's group for a cutting-edge project in therapeutic epigenome editing. This role focuses on developing and optimizing epigenome editing strategies for robust gene regulation in clinically relevant targets, leveraging next-generation CRISPR technologies and in vivo experimental systems. The position is translational and milestone-driven, with a strong emphasis on R&D that bridges academia and biotech, in collaboration with Epitome Therapeutics.

Key responsibilities include designing and testing epigenome editing strategies, building and executing liver screening pipelines, generating RNA-seq and phenotypic readouts, and iteratively optimizing toward therapeutic-level performance. The ideal candidate will have a PhD in biology, biomedical sciences, or a related field, with hands-on experience in in vivo work, CRISPR or epigenome editing, and RNA-seq. The role is suited for individuals who are reliable, execution-focused, and impact-driven, and who enjoy building robust experimental systems.

The successful applicant will benefit from a competitive salary, full health coverage, and the opportunity to co-lead next-generation CRISPR therapeutic development in an international environment. The position offers direct exposure to technology transfer and company building, with all work based in Rome, Italy, providing an exceptional quality of life. The application process is managed through the EMBL careers portal, and interested candidates should apply via the provided link for further details.

Research areas include epigenome editing, therapeutic gene regulation, CRISPR, precision medicine, translational research, RNA-seq, in vivo experimentation, liver screening, and biotechnology. This opportunity is ideal for those passionate about advancing the field of epigenetics and contributing to the future of precision medicine.