Postdoctoral Researcher in MicroRNA Regulation of γδ T Cell Differentiation and Malaria Response Gulbenkian Institute for Molecular Medicine in Portugal

The Gulbenkian Institute for Molecular Medicine (GIMM) in Lisbon, Portugal, is seeking a Postdoctoral Researcher to join a cutting-edge project investigating microRNA regulators of γδ T cell subset differentiation and their response to malaria infection. GIMM is a newly established private research foundation formed from the merger of two leading institutes, dedicated to fundamental scientific exploration and global health impact. The research will focus on the functional specialization of γδ T cell subsets, defined by IL-17 (γδ17) or IFN-γ (γδIFN) production, and their distinct roles during malaria infection.

The successful candidate will use preliminary data identifying miRNAs differentially expressed between γδ T cell subsets to modulate candidate miRNAs in vitro and in vivo, identify direct mRNA targets through Ago-IP, bioinformatic prediction, and luciferase assays, and validate key findings in γδ T cells activated with Plasmodium spp. The project also explores intracellular organelle organization and vesicular trafficking as additional mechanistic layers governing γδ T cell specialization, integrating quantitative transmission electron microscopy data with transcriptomic analyses to define vesicular and organelle architecture and associating ultrastructural features with gene expression and function related to membrane trafficking and autophagy pathways.

Applicants must hold a PhD in Biological Sciences (including Biology, Biochemistry, Biomedicine, or related fields) and have less than 3 years of postdoctoral experience. Solid experience in molecular biology, particularly RNA studies, is required. Desirable qualifications include experience in primary cell culture, transfection or transduction (ideally lymphocytes), background in immunology, experience with murine models, and flow cytometry. The position offers a gross monthly remuneration of 2408.11€, funded by FCT and the Lisbon Regional Programme 2030 (ERDF funds). The contract is expected to start in September 2026 and will last for the necessary execution period of the work plan, with activities based at GIMM installations in Lisboa/Oeiras.

The selection process involves evaluation of scientific production, research experience, and curriculum adequacy to the work plan, followed by interviews for top candidates. Applications must include a detailed CV, motivation letter, PhD certificate, and contacts of two references, submitted in PDF format to [email protected] with the reference 'GIMM/CT/18-2026' in the subject line. The application deadline is 5 June 2026. GIMM promotes a non-discrimination and equal access policy, fostering an international, inclusive, and stimulating research environment.

For further information, visit GIMM website or the position link. For application queries, contact [email protected].