Regulation of Amylin 1 Receptor Signalling by Lipids in Obesity and Diabetes (PhD Position) Coventry University in United Kingdom

This fully funded PhD position at Coventry University, offered through the Midlands Integrative Biosciences Training Partnership (MIBTP), investigates the regulation of the amylin 1 receptor (AMY1R) by membrane lipids in the context of obesity and diabetes. AMY1R, a G-protein-coupled receptor (GPCR) and member of the calcitonin receptor family, is crucial for satiety, glycaemic control, and neurovascular function. Despite its therapeutic relevance, the molecular mechanisms of AMY1R activation and signalling are not well understood, particularly how membrane lipids modulate its behaviour.

The project employs an interdisciplinary approach, combining advanced lipidomics, bioluminescence-based GPCR functional assays, and computational modelling to elucidate lipid-receptor interactions. Key objectives include characterising the lipid environment of AMY1R in physiologically relevant membranes using detergent-free solubilisation techniques (SMA-like polymers) and mass spectrometry-based lipidomics, assessing the impact of lipid profiles on ligand binding and intracellular signalling via nanoBRET-based assays, and developing predictive models of lipid-sensitive AMY1R pharmacology through in silico simulations.

By decoding the crosstalk between lipids and AMY1R, the research aims to inform the design of next-generation therapeutics for metabolic diseases, aligning with BBSRC's strategic priorities in health, structural biology, and biotechnology. The successful candidate will receive comprehensive training in membrane protein biochemistry, molecular pharmacology, advanced mass spectrometry, and molecular modelling, working within a collaborative research group at Coventry University's Centre for Health and Life Sciences. Opportunities for publication, conference presentations, and industrial engagement are actively supported.

The studentship includes full tuition fees (UK rate), with Coventry University covering the difference for international students, a tax-free annual stipend (£20,780 for 2025-26), a travel/conference budget, a generous consumables budget, and the use of a MacBook Pro for the duration of the programme. Applicants must have a minimum of a 2:1 first degree in a relevant discipline, with at least 60% in the project element and a minimum 60% overall module average. Non-native English speakers must demonstrate proficiency with an IELTS Academic score of 7.0 (minimum 6.5 in each section) or TOEFL iBT score of 95 (minimum 21 in each section).

To apply, candidates should check their eligibility, complete the ED&I form (which also serves as an expression of interest), fill out the application form, and review the MIBTP Data Privacy Policy. For administrative questions, contact [email protected]. The application deadline is November 27, 2025.