Understanding Developmental Trajectories Underlying the Effects of Early Life Stress on Neurodevelopment and Function Aston University in United Kingdom

This PhD project at Aston University investigates how early brain development influences stress regulation, with a focus on the genetic and developmental factors underlying vulnerability to psychiatric disorders such as schizophrenia, depression, and anxiety. Using zebrafish as a model system, the research leverages the species' genetic tractability and transparency for live imaging to study the role of the psychiatric risk gene Disrupted-In-Schizophrenia-1 (DISC1) in shaping stress-regulating circuits of the hypothalamus.

The project will employ advanced imaging, molecular genetics, behavioural assays, and bioinformatics to explore how DISC1 and related pathways affect the development and function of neurons controlling stress. Students will receive comprehensive training in zebrafish developmental neurobiology, stress physiology, and cutting-edge research techniques, preparing them for interdisciplinary research careers.

This opportunity is ideal for candidates with backgrounds in neuroscience, developmental biology, genetics, or biomedical science. The research is based at the Aston Campus in Birmingham, UK, and students are expected to attend in person regularly. The project is funded for Home tuition fees; overseas applicants are welcome but must cover the difference between Home and Overseas fees (£17,712 for 2026/7).

Applicants must hold, or expect to achieve, a First or Upper Second Class undergraduate degree (or equivalent) in a relevant subject, or a Merit in a relevant Masters degree plus an undergraduate degree. Applications must include transcripts, certificates, a research statement, personal statement, CV, and two academic references. Evidence of English language proficiency and a copy of your passport are also required. Interviews will be conducted online for shortlisted candidates.

For further information, contact Dr Helen Eachus at [email protected]. Apply online by selecting 'Research - Health Sciences' on the application form. Year-round applications are accepted, but only complete applications with all supporting documents will be considered.