Chris Toseland

This fully funded PhD project, part of the BBSRC Yorkshire Bioscience Doctoral Training Partnership (YBDTP), offers an exciting opportunity to investigate the role of the molecular motor myosin VI (MVI) in DNA repair and its potential as a therapeutic target in cancer. Hosted at the University of Sheffield within the School of Medicine and Population Health, the project is supervised by Professor Chris Toseland, Dr Matt Newton, and Professor Klaus Pors, who collectively bring expertise in cancer biophysics, biosciences, and chemical biology. The research aims to understand how MVI contributes to the dynamic reorganisation of chromatin required for transcription and DNA repair, with the goal of identifying new strategies to sensitize cancer cells to chemotherapy and improve patient outcomes. The project employs an interdisciplinary toolkit, including single-molecule localisation microscopy, CRISPR genome editing, protein biochemistry, and in vivo tumour xenografts, providing both mechanistic and translational research training. Students will benefit from world-class facilities, a collaborative and supportive research community, and a vibrant PhD cohort with regular social and professional development events. The YBDTP programme emphasizes interdisciplinary collaboration and professional skill development, preparing graduates for both academic and non-academic bioscience careers. The studentship is open to UK, EU, and international applicants with at least an upper second-class honours degree (or equivalent) in a relevant scientific discipline. The funding package includes a tax-free stipend at the UKRI rate (£20,780 for 2025/26), research costs, and tuition fees at the UK rate, with a limited number of full studentships available for exceptional international candidates. Applicants from underrepresented backgrounds are especially encouraged to apply. The application deadline is 7 January 2026, and the process involves submitting an expression of interest form. Shortlisted candidates will be invited for interview, and successful applicants must confirm acceptance within 10 days. For further information, prospective students can contact Prof Chris Toseland or the YBDTP administration.

A PhD opportunity is available within the group of Professor Chris Toseland at The University of Sheffield, as part of the BBSRC Yorkshire Bioscience DLA Programme. The project focuses on understanding how the Oestrogen receptor globally regulates transcription across the genome during development, a key question in developmental biology and cancer biophysics. The research will likely involve molecular biology, genomics, and bioinformatics approaches to dissect the mechanisms of transcriptional regulation. The University of Sheffield is a leading research institution in the United Kingdom, and the BBSRC DLA Programme provides a collaborative and interdisciplinary training environment. Applicants should have a strong background in biology, biochemistry, or a related field, and an interest in molecular and developmental biology. Funding is typically provided for tuition and a stipend, but candidates should consult the programme website for full details. Interested applicants are encouraged to follow the provided link for more information and to apply.

A PhD opportunity is available within the group of Professor Chris Toseland at the University of Sheffield, focusing on the role of Nuclear Myosin VI in supporting DNA repair and its potential as a therapeutic target. This project is part of the BBSRC Yorkshire Bioscience Doctoral Training Programme, which aims to train the next generation of bioscientists in cutting-edge research. The research will explore the molecular mechanisms by which Nuclear Myosin VI contributes to DNA repair processes, with implications for cancer biology and the development of new therapeutic strategies. The University of Sheffield provides a vibrant research environment and access to state-of-the-art facilities. Interested candidates should review the full project details and application instructions via the provided FindAPhD link. The post does not specify funding or eligibility requirements, so applicants are encouraged to consult the official project page or contact the supervisor for further information.