Postdoctoral Position – Decoding Neurodevelopmental Trajectories at Single-Cell Resolution in a PTBP1-STAD Syndrome Mouse Model
Inserm UMR 1231, located in Dijon, France, offers a postdoctoral position in the GAD team, focusing on decoding neurodevelopmental trajectories at single-cell resolution in a PTBP1-STAD syndrome mouse model. Inserm is France’s premier public research organization dedicated to biological, medical, and population health research, providing a collaborative and interdisciplinary environment with access to state-of-the-art facilities in cell biology, genomics, transcriptomics, proteomics, advanced microscopy, and bioinformatics.
The GAD team, led by Professors Antonio Vitobello and Christel Thauvin, investigates the molecular bases of neurodevelopmental and neurodegenerative disorders. The OMICS group specializes in understanding disease mechanisms and developing new therapeutic strategies. This ANR-funded project aims to characterize the neurodevelopmental and skeletal trajectories of STAD syndrome (Masson-Paccaud-Vitobello syndrome) using a knock-in mouse model and patient-derived cerebral organoids. The research leverages advanced omics technologies, including single-cell and spatial transcriptomics, alongside cell and molecular assays, to dissect the underlying mechanisms of disease.
The successful candidate will prepare and process developmental samples for cellular, molecular, and single-cell/spatial transcriptomic analyses, perform histological characterization, immunostaining, and advanced imaging to assess neuroanatomy and cytoarchitecture, and design, execute, and troubleshoot experiments independently. Responsibilities also include maintaining and breeding mouse lines, collaborating with bioinformaticians, postdocs, and PhD students, disseminating results through scientific publications and conference presentations, participating in ongoing team projects, supervising Master’s and PhD students, applying for funding opportunities, and engaging in lab meetings and scientific discussions.
Applicants must hold a PhD in Neuroscience, Systems Biology, Developmental Biology, or a related field with omics-oriented skills. Candidates finalizing their PhD should provide their expected defense date. Required skills include strong experience in histological characterization of brain development and cytoarchitecture, proficiency in immunohistochemistry and advanced imaging, cell and molecular biology expertise, hands-on experience with mouse models (including a valid permit for laboratory animal handling), and familiarity with single-cell or spatial transcriptomics. Bioinformatics skills, particularly independent data mining and exploratory analyses, are highly desirable. Excellent command of English, autonomy, initiative, adaptability, strong analytical and problem-solving skills, and communication abilities are essential. Eligible candidates should have 0 to 4 years of experience after PhD.
The position is funded by the French National Research Agency (ANR) for 24 months (not renewable), with salary depending on professional experience. The laboratory provides full support for candidates wishing to apply for independent fellowships (EMBO, MSCA, or equivalent). Inserm UMR 1231 is committed to gender parity, professional equality, diversity, and support for employees with disabilities, offering a fair balance between personal and professional life.
To apply, send a detailed CV, cover letter, and names and contact details of two referees to [email protected] before 2026-04-30, including the subject line 'APPLICATION-PTBP1‑U1231_NAME‑SURNAME'. For more information, visit the Inserm UMR 1231 website or contact the Disability Unit at [email protected] for workplace adjustments.
