Cindy Smith

The University of Glasgow is offering a funded PhD opportunity in the area of microbiology, phages, and water security. The project, supervised by Dr Giusy Mariano (School of Infection and Immunity) and Prof Cindy Smith (James Watt School of Engineering), focuses on the targeted control of pathogens in drinking-water biofilters. The research aims to test bacteriophages as a sustainable and biofilter-friendly alternative to chlorine for controlling persistent pathogens such as Pseudomonas, Enterococcus, non-tuberculous Mycobacterium, and Legionella in water treatment systems. Biofilters are essential for maintaining beneficial microbial communities that clean drinking water, but they can also harbor opportunistic pathogens. Traditional chlorination cannot be used within biofilters without harming these beneficial microbes. This project will explore the use of phages to selectively target and remove pathogens while preserving the biofilter's function. The research will employ metagenomics, phage discovery, and experimental lab columns to assess the effectiveness of phage treatments, track microbial community changes, and evaluate bacterial resistance mechanisms such as CRISPR-Cas systems. The project will provide insights into the ecological dynamics of phage-host interactions, develop effective phage combinations, and establish dosing and monitoring strategies to minimize resistance and maintain water quality. The findings will contribute to sustainable pathogen control in water treatment and offer broader principles for phage–microbiome interactions in complex environments. Applicants should have a strong background in microbiology, environmental science, or related disciplines, with experience in metagenomics or water treatment considered an asset. The position is fully funded, covering tuition and providing a stipend. For more information and to apply, visit the University of Glasgow's College Futures Themes PhD Programme website.