This fully funded PhD project at the University of Bristol investigates the mechanisms of pattern separation in the hippocampal dentate gyrus (DG), a process crucial for distinguishing similar memories and one of the earliest to decline with age. The research focuses on the role of CCK-interneurons, a relatively understudied class of GABAergic interneurons within the DG, which express endocannabinoid receptors and may be key modulators of network activity and memory encoding. The project combines experimental approaches—including electrophysiology, pharmacology, optogenetics, and advanced genetic and imaging techniques—with computational modeling to understand how these interneurons contribute to the balance of excitation and inhibition in DG microcircuitry. The student will join an interdisciplinary team and use Python-based simulations on high-performance computing platforms to predict how pharmacological agents, such as cannabinoid agonists, may affect pattern separation and memory precision. The findings aim to inform therapeutic strategies for memory decline associated with aging and neurological disorders. The SWBio DTP program offers outstanding interdisciplinary bioscience training, with support for students from diverse backgrounds and circumstances, including flexible and part-time study options. The studentship covers a four-year duration, an annual stipend of £20,780, full tuition fees, research costs, and additional funds for fieldwork, conferences, and a placement. Up to 30% of studentships are available for international applicants. Applicants should have a strong background in neuroscience, biology, or related fields, and an interest in the experimental and computational techniques described. The application deadline is December 3, 2025, and further details on how to apply are available via the SWBio DTP website.