Dr D Arseni

This PhD project is based at the Medical Research Council (Cambridge) and investigates the mechanisms underlying brain health, ageing, and disease, with a particular focus on the lysosomal protein transmembrane protein 106B (TMEM106B). TMEM106B has been shown to form amyloids in the brain in an age-dependent manner, and the group aims to understand how this process contributes to neurodegeneration and other age-related brain disorders. The research will involve studying the molecular and cellular mechanisms of TMEM106B amyloid formation, its impact on lysosomal function, and its broader implications for brain health and disease. The project is suitable for students interested in neuroscience, molecular biology, and disease mechanisms. The Medical Research Council (Cambridge) provides a vibrant research environment with access to state-of-the-art facilities and expertise in neurobiology and ageing research. Funding details, application requirements, and deadlines are not specified in the current description.