Heidi Jacobs

Open postdoctoral fellow position in Alzheimer's disease , noradrenergic system research, and advanced neuroimaging at the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital / Harvard Medical School in Boston. The project focuses on understanding how the noradrenergic locus coeruleus system contributes to Alzheimer’s disease pathophysiology, symptoms, and progression. The work integrates PET , 7T MRI (structural MRI, functional MRI, magnetic resonance spectroscopy), pupillometry, physiological recordings, blood-based markers, cognitive assessments, and cognitive computational modeling. There is also scope for observational studies, pharmacological challenges, and other perturbational approaches. The lab’s broader research mission is to improve early detection of Alzheimer’s disease and evaluate targeted interventions to delay cognitive decline. The environment is highly collaborative and multidisciplinary, with ongoing work across imaging, biofluids, wearables, behavioral measures, and non-invasive neurostimulation. Eligibility highlights: applicants should have a PhD in Cognitive Neuroscience, Computational Modeling, Biomedical Physics, Biomedical Engineering, Neuroscience, or a related field. Strong publication record, experience with neuroimaging and computational modeling, programming skills (Python/MATLAB), signal processing background, and the ability to work with longitudinal datasets are emphasized. Experience in Alzheimer’s disease or aging research is a plus. Funding: the position is supported by NIH and foundation grants. The postdoc will be based at MGH/HMS and work within the Martinos Center in Charlestown, Boston. How to apply: send a CV, cover letter, and references to Dr. Heidi Jacobs at [email protected]. More information is available on the lab website and Martinos Center pages.