J Hardwick

This fully funded PhD project at the University of Bristol investigates how neurons interpret epigenetic information encoded in DNA, focusing on modifications such as methylation and hydroxymethylation. These modifications are crucial in the brain, influencing learning, memory, and neurological diseases like Alzheimer’s. The project aims to decipher how these epigenetic marks affect DNA-protein interactions in neurons, with two main objectives: to understand how DNA modifications alter chromatin structure and to identify neuronally expressed proteins that interact with modified DNA. The research will be conducted in the DNA-Protein Interactions Unit at the School of Biochemistry, providing access to advanced proteomics facilities and biophysical instruments for characterizing DNA-protein interactions at both ensemble and single-molecule levels. The project is supported by a multidisciplinary supervisory team, including Prof Jonathan Mill (University of Exeter), an expert in neurodegeneration epigenomics, and Prof Mark Dillingham (University of Bristol), an expert in DNA-protein interactions. The Mill lab will provide cutting-edge epigenomic data from Alzheimer’s patient neurons to inform experimental design. The program offers a stimulating and supportive environment, with opportunities for collaboration in DNA sequencing, neuroepigenetics, and bioinformatics. Candidates should have a degree in chemical or biological sciences; prior experience in the specific techniques is not required, as comprehensive training will be provided. The program encourages applications from diverse backgrounds and is committed to inclusivity, offering reasonable project adaptations and flexible study options. The BBSRC-funded SWBio DTP partnership provides outstanding interdisciplinary bioscience research training, with up to 34 fully funded 4-year PhD studentships available to start in September 2025. The studentship covers an annual stipend of £20,780 (2025/26), full tuition fees, research costs, and additional funds for fieldwork, conferences, and a 3-month placement. Paid sick leave and parental leave are also available. Up to 30% of studentships are open to international applicants. The application deadline is December 3, 2025. For more information or informal enquiries, candidates are encouraged to contact Dr Hardwick.