PhD position – Research on congenital left sided heart lesions: Impact Of Multi-Omics and Clinical Integration
This PhD position at KU Leuven is embedded within the Department of Cardiovascular Sciences, in close collaboration with Human Genetics, and forms part of a European interdisciplinary project spanning Pediatric Cardiology, Human Genetics, Gynecology, and Neonatology. The research environment is highly supportive, fostering both fundamental and translational studies of congenital heart diseases. The project specifically addresses the wide spectrum of congenital left sided heart lesions in children, including severe conditions such as hypoplastic left heart syndrome and aortic stenosis, as well as milder forms like coarctation of the aorta.
Despite advances in surgical interventions, children with left sided heart disease may experience impaired systemic circulation and oxygen delivery, which can negatively impact long-term cardiovascular and neurological outcomes. This PhD research aims to bridge genetic analysis in mother-child pairs, cardiac morphology, and postnatal clinical presentation, combining genetic and clinical outcome parameters to develop a screening and risk stratification model for left sided heart lesions.
The project integrates multi-omics technologies, clinical cardiac and neurological investigations, and machine learning to enhance early diagnosis and risk stratification. Both genetic and clinical data will be leveraged to develop targeted diagnostic tools and personalized treatment approaches. The successful candidate will coordinate patient inclusion, ensure the performance of all investigations, and analyze clinical data, including cardiac imaging, neuro monitoring, and laboratory parameters. This innovative approach will provide detailed clinical assessments and significantly improve understanding of congenital left sided heart diseases.
Throughout the project, the PhD student will collaborate closely with a multidisciplinary team in pediatric cardiology, human genetics, gynecology, neonatology, and intensive care medicine. The position offers access to clinical treatment and basic research facilities, integration into the European research landscape, and opportunities to build research and innovation skills. Attendance at international conferences and networking events is encouraged.
Funding is secured for 3 years, with the intention to extend to 4 years. Applicants should hold a master's degree in medicine, biomedical science, neuroscience, or bioengineering. Experience in cardiac hemodynamics, neuromonitoring, or neurovascular coupling is advantageous. Candidates must demonstrate creativity, analytical skills, and an interest in coordinating tasks. Excellent oral and written communication skills in English (Dutch is preferable), flexibility, precision, motivation, and the ability to work both independently and as part of a multidisciplinary team are required. The candidate will coordinate the clinical study, work with patient data, communicate with the international consortium, and participate in grant writing and funding acquisition.
KU Leuven is committed to an inclusive, respectful, and socially safe environment, embracing diversity and equal opportunity. For accessibility or support questions, assistance is available via the provided contact emails.
Interested candidates should apply online via the KU Leuven job portal. For more information, contact Prof. dr. Ruth Heying or Prof. dr. Jeroen Breckpot by email. Ensure your application is submitted before the deadline of April 30, 2026.
