John MacKay

Project Overview: This fully funded PhD project, titled "Vaccinating forest trees against insect pests (JMK01)", is an industrial-CASE collaboration focused on the cutting-edge field of epigenetic priming for plant protection. Hosted by the Molecular Plant Biology section in the Department of Biology at the University of Oxford, the research aims to harness epigenetic changes—such as chromatin modification and DNA methylation—to prime natural plant defences in conifer trees, offering a sustainable alternative to chemical pesticides. Research Focus: The project investigates the molecular mechanisms underlying defence priming in conifer species ( Picea sitchensis and Pinus sylvestris ) against the weevil Hylobius abietis , a major forest pest in the UK and Europe. By applying small molecules like jasmonic acid (JA), the research explores how long-lasting epigenetic changes can enhance resistance to pests, while evaluating potential trade-offs in tree growth and reliability for practical forestry applications. The study integrates field evaluations, laboratory experiments, and advanced genomic analyses to uncover the genetic and biochemical basis of plant-insect interactions. Training & Environment: The successful candidate will join the ForestTree Biology group in the new Life and Mind Building at Oxford, receiving comprehensive training in computational methods, programming, forest genomics, and plant-insect interaction research. The project includes a 12-week industry internship with Forestart, a leading UK seed provider, covering seed processing, controlled pollinations, and priming treatments. The skills developed are highly transferable to careers in environmental monitoring, applied genetics, and sustainable pest management. Supervision: The project is supervised by Professor John MacKay, an expert in forest tree genomics, and Dr. Rebecca Mosher, a specialist in plant epigenetics and development. The group fosters an inclusive and collaborative research culture, encouraging applications from motivated individuals of all backgrounds. Funding & Eligibility: The position is funded through the Interdisciplinary Life and Environmental Sciences Landscape Award (ILESLA), covering UKRI standard stipend and home student fees. It is open to all nationalities, but overseas students may need to secure additional funding for the difference in fees. Late applications will not be considered for scholarship funding. Requirements: Applicants should hold a degree in biological sciences or a related discipline, demonstrate interest or experience in genomics and experimental research with plants and insects, and be able to work both independently and collaboratively. Training and short rotation projects are required before final project commitment. Application Process: Interested candidates should send a statement of interest, CV, and academic transcripts to Professor John MacKay ([email protected]) for informal inquiries. Formal applications are submitted via the MPLS Doctoral Training Centre ( application link ). The deadline for 2026/27 entry is 8 January 2026. References & Further Information: For more on the scientific background, see recent publications on epigenetic stress memory and jasmonic acid-dependent immunity in conifers. For details on the programme and funding, visit the Department of Biology DPhil page and the application portal .