This BBSRC-funded postdoctoral position at the University of Oxford offers an exciting opportunity to join a multidisciplinary team working on Single Molecule Proteomics. Led by Professor Justin Benesch, the project brings together researchers from Oxford, Liverpool, and Cambridge to develop a novel platform for identifying proteins and their modifications, with a particular focus on phosphorylation—a key regulator of protein function that remains challenging to study with current technologies. The successful candidate will contribute to protein production, purification, and the analysis of constructs to test new devices developed by the group. Expertise in structural and conformational analysis using mass spectrometry is essential, as this will be critical for validating the reagents and advancing the project’s goals. The role involves managing academic research and administrative activities, including small-scale project management to coordinate multiple aspects of the work and meet deadlines. Applicants should have a PhD in a relevant field such as protein biochemistry or chemistry, and demonstrate experience in the required techniques. Applications are particularly encouraged from women and black and ethnic minority candidates, who are under-represented in Chemistry research posts at Oxford. The Department of Chemistry holds a Silver Athena SWAN award, reflecting its commitment to equality and diversity. The application process requires a supporting statement and CV, with the statement detailing how the candidate meets each selection criterion using specific examples. Certificates, references, and research papers should not be provided at this stage. The closing date for applications is 12.00 midday on 2 October 2025, with interviews to follow soon after. This position provides a unique opportunity to contribute to cutting-edge research at the intersection of protein science, chemistry, and health, within a collaborative and supportive academic environment.

This BBSRC-funded postdoctoral position in Single Molecule Proteomics is hosted at the University of Oxford, in collaboration with the Universities of Liverpool and Cambridge. Led by Professor Justin Benesch, the project aims to revolutionize protein identification and the study of post-translational modifications, particularly phosphorylation, which is crucial for protein function but challenging to detect with current technologies. The research team is developing a novel platform to uncover the hidden dynamics of proteins in both health and disease contexts. As a postdoctoral researcher, you will work at the intersection of computational biology, molecular biophysics, and advanced analytical technologies. Your main responsibilities will include developing and applying computational methods to study protein folding, structure, and interactions. The ideal candidate will have strong expertise in protein structure prediction, molecular modelling, and docking, as well as proficiency in LINUX, bash scripting, and high-performance computing. Advanced programming skills in Python are essential, and experience with computational approaches to protein folding and molecular dynamics simulation tools such as GROMACS is highly desirable. A solid foundation in molecular biology, including protein expression and purification, understanding of protein-peptide interactions, and knowledge of mass spectrometry techniques, is also expected. The project offers a unique opportunity to work alongside leading scientists such as Philipp Kukura, Dirk Aarts, Hagan Bayley, Madhavi Krishnan, Yujia Qing, Yarin Gal, Kevin Foster, Claire Eyers, and Sarah Teichmann. The collaborative and intellectually stimulating environment is ideal for researchers passionate about uncovering new layers of protein biology. The position is fully funded by the BBSRC, covering salary and research costs. Applications are particularly encouraged from women and black and ethnic minority candidates, who are under-represented in Chemistry research posts at Oxford. The application deadline is 9 October 2025, with interviews to follow soon after. Applicants should submit an online application including a supporting statement and CV, clearly demonstrating how they meet the selection criteria. Certificates, references, and research papers are not required at this stage.