Matthias Herth

The Herth Group at the University of Copenhagen is recruiting three postdoctoral researchers for 2-year positions in the fields of radiopharmaceutical chemistry, medicinal/organic chemistry, and translational radiochemistry & technology. The research focuses on the development of next-generation astatinated radiopharmaceuticals for cancer therapy, including neuroendocrine tumors and ovarian cancer, with projects spanning from discovery to clinical translation. The positions are embedded in a highly interdisciplinary and translational environment, involving close collaboration with GMP production, clinical application, and industrial partners. Research areas include radiopharmaceutical chemistry (development of new radiolabeling strategies for astatine-211–labeled drug candidates), medicinal/organic chemistry (structure–activity relationship studies, optimization of lead compounds, and development of molecular targeting modules for CAR T cell therapy), and translational radiochemistry (automation, upscaling, and transfer to synthesis modules). The group employs advanced radiolabelling technologies, machine-learning-supported optimization, and a bench-to-bedside approach, targeting both small molecules and larger biomolecules such as monoclonal antibodies and nanobodies. Applicants should have a PhD in a relevant field (radiochemistry, radiopharmaceutical chemistry, engineering, medicinal chemistry, or organic chemistry), strong hands-on experience, and a clear interest in translational drug development. The positions offer creative and stimulating working conditions in a dynamic, international research environment, with access to modern laboratories and advanced radiochemistry infrastructure. The monthly salary starts at 39,000 DKK (approx. 5,200 EUR), with a 17.1% pension contribution and potential tax reductions for eligible foreign applicants. The application deadline is March 1, 2026, and the expected start date is June 1, 2026, or shortly thereafter. For more information, visit the official job postings or contact Professor Matthias Herth at [email protected]. Application materials must include a motivated letter, CV, degree certificates, and publication list, submitted online via the provided links.

PhD fellowship at the Biotech Research and Innovation Centre (BRIC) / Finsen Laboratory , Faculty of Health and Medical Sciences, University of Copenhagen , in antibody-drug conjugate (ADC) engineering with a focus on internalization and lysosomal delivery . The project aims to engineer and test next-generation ADCs with improved trafficking and payload release. Research includes bispecific constructs, established ADC targets such as uPAR , MMP14 , uPARAP , and the Mannose Receptor , plus receptors that promote lysosomal delivery such as IGF2R . Lead candidates will be evaluated in cancer cell models and in vivo, including sarcoma and glioblastoma models. This PhD is part of a Novo Nordisk Foundation Distinguished Innovator project, Breaking Barriers: Engineering ADCs for Efficient BBB Transport and Lysosomal Targeting , in collaboration with Professor Matthias Herth (Department of Drug Design and Pharmacology, UCPH) and Professor Katrine Qvortrup (Department of Chemistry, DTU). Key work includes recombinant antibody production and purification, payload conjugation, ADC characterization, cell-based uptake/internalization assays, flow cytometry, drug screening, cytotoxicity and viability assays, and in vivo efficacy studies. The position also includes PhD coursework, teaching/dissemination, participation in active research environments, and writing a PhD thesis. Eligibility highlights: an MSc in pharmaceutical biotechnology, biotechnology, or a closely related field; strong hands-on ADC experience; experience with mammalian cancer cell assays, flow cytometry, and laboratory animal work; excellent English; and an international research background. Functional genomics and sarcoma model experience are advantageous. The fellowship is full-time for 3 years, with salary and pension under Danish state agreements. The monthly salary starts at approximately 31,800 DKK (about 4,200 EUR , August 2026 level) plus pension. Deadline: 6 November 2026, 23:59 CET. Apply online through the university portal and upload the required documents (motivation letter, CV, MSc diploma/transcript, and publication list if available).