Monica Craciun

[£20,780 per year stipend.] PhD Opportunity: Development of Nanoengineered Wireless Graphene Sensors for Real-Time Neurochemical Monitoring The University of Exeter invites applications for a fully funded PhD project focused on the development of a wireless, nanoengineered graphene-based biosensor for real-time dopamine (DA) detection. This innovative project aims to address critical challenges in neurochemical monitoring by leveraging the unique electrochemical properties of graphene, advanced nanoengineering techniques, and wireless technology to create a sensor with superior sensitivity, selectivity, and stability. Project Overview: The primary objective is to design and fabricate a wireless biosensor capable of chronic, real-time monitoring of dopamine, a key neuromodulator involved in physiological processes such as reward, motivation, and motor control, as well as in disorders like Parkinson's disease and addiction. The project will integrate nanoengineered graphene with wireless electronics, enabling seamless operation in dynamic neuromodulation systems and closed-loop therapeutic interventions. Research Methodology: - Synthesis and Characterisation: Multilayer graphene will be synthesized via chemical vapor deposition (CVD) and transferred to flexible substrates. Nanoengineering will enhance DA detection through defect and doping strategies, with characterization by Raman spectroscopy, SEM, AFM, and electrochemical analysis. - Wireless Integration: The sensor will be embedded with low-power electronics and a dual-band implantable antenna for efficient wireless communication and power transmission. Real-time data transmission and signal conditioning will be optimized for stable operation in complex biological environments. - Selectivity and Interference Analysis: The sensor’s ability to distinguish DA from common interferants (e.g., uric acid, ascorbic acid, norepinephrine, serotonin) will be rigorously tested, ensuring reliable performance for clinical and research applications. Supervision and Environment: The project will be supervised by Dr Rupam Das and Prof Monica Craciun, experts in biosensor technology and nanomaterials. The successful candidate will join a vibrant research community at the University of Exeter, benefiting from state-of-the-art facilities and interdisciplinary collaboration. Funding: A stipend of £20,780 per year is available for the duration of the PhD. Eligibility: Applicants should have a strong background in biomedical engineering, materials science, chemistry, electrical engineering, or a related field. Experience with nanomaterials, biosensors, or wireless electronics is advantageous. English language proficiency is required for non-native speakers. Application Process: Apply online via the University of Exeter portal using the provided link. For project-specific enquiries, contact Dr Rupam Das ([email protected]) or Prof Monica Craciun ([email protected]). The application deadline is 12 January 2025.

[£20,780 per year stipend.] Project Overview: This fully funded PhD position at the University of Exeter offers an exciting opportunity to develop a cutting-edge wireless, nanoengineered graphene-based biosensor for real-time dopamine (DA) detection. The project is designed to advance neurochemical monitoring technologies, enabling chronic, untethered measurement of DA for both clinical and research applications. The sensor’s wireless capabilities will facilitate integration into dynamic neuromodulation systems, supporting closed-loop therapeutic interventions for neurological disorders. Research Context: Biosensor technology is rapidly evolving to meet the demands of modern biomedical research, particularly for real-time monitoring of biomolecules like dopamine—a key neuromodulator involved in reward, motivation, motor control, and diseases such as Parkinson’s and addiction. Current methods lack the precision and dynamic feedback required for advanced therapeutic applications. This project leverages graphene’s exceptional electrochemical properties, enhanced through nanoengineering, to overcome these limitations and deliver a high-performance, selective, and stable DA biosensor. Methodology: Synthesis and Characterisation of Nanoengineered Graphene: Multilayer graphene will be synthesized via chemical vapor deposition (CVD) on nickel substrates, transferred to flexible polyimide substrates, and nanoengineered using defect introduction (electron beam lithography, plasma treatments) and doping (Ni-doped V₂O₅, CeO₂ nanoparticles, boron/nitrogen-doped quantum dots). Characterisation will employ Raman spectroscopy, SEM, AFM, and electrochemical analysis (CV, FSCV) to optimize DA detection. Integration of Wireless Functionality: The sensor will be embedded on a flexible substrate with wireless electronic components, including a dual band implantable antenna for communication and power, low-power signal conditioning electronics, and reliable data transmission to external receivers for real-time DA monitoring. Selectivity and Interference Analysis: Sensor performance will be validated in solutions containing DA and common interferants (uric acid, ascorbic acid, norepinephrine, serotonin, DA metabolites), ensuring high selectivity and stable wireless operation in complex environments. Supervision and Research Environment: The project will be supervised by Dr Rupam Das and Prof Monica Craciun, experts in biosensors and advanced materials. The University of Exeter provides a vibrant research environment with access to state-of-the-art facilities for nanomaterials synthesis, device fabrication, and neurochemical analysis. Funding: The position offers a competitive stipend of £20,780 per year, supporting tuition and living expenses. Eligibility: Applicants should have a strong background in engineering, physics, materials science, biomedical sciences, or related fields. Experience with nanomaterials, biosensors, or electrochemical analysis is desirable. International candidates may need to demonstrate English language proficiency. Application Process: Applications are open until 12 January 2026. Interested candidates should apply via the University of Exeter funding page and contact the supervisors for project-specific queries. Contact: Dr Rupam Das ([email protected]), Prof Monica Craciun ([email protected])