Monica Craciun

[£20,780 per year stipend.] PhD Opportunity: Development of Nanoengineered Wireless Graphene Sensors for Real-Time Neurochemical Monitoring The University of Exeter invites applications for a fully funded PhD project focused on the development of a wireless, nanoengineered graphene-based biosensor for real-time dopamine (DA) detection. This innovative project aims to address critical challenges in neurochemical monitoring by leveraging the unique electrochemical properties of graphene, advanced nanoengineering techniques, and wireless technology to create a sensor with superior sensitivity, selectivity, and stability. Project Overview: The primary objective is to design and fabricate a wireless biosensor capable of chronic, real-time monitoring of dopamine, a key neuromodulator involved in physiological processes such as reward, motivation, and motor control, as well as in disorders like Parkinson's disease and addiction. The project will integrate nanoengineered graphene with wireless electronics, enabling seamless operation in dynamic neuromodulation systems and closed-loop therapeutic interventions. Research Methodology: - Synthesis and Characterisation: Multilayer graphene will be synthesized via chemical vapor deposition (CVD) and transferred to flexible substrates. Nanoengineering will enhance DA detection through defect and doping strategies, with characterization by Raman spectroscopy, SEM, AFM, and electrochemical analysis. - Wireless Integration: The sensor will be embedded with low-power electronics and a dual-band implantable antenna for efficient wireless communication and power transmission. Real-time data transmission and signal conditioning will be optimized for stable operation in complex biological environments. - Selectivity and Interference Analysis: The sensor’s ability to distinguish DA from common interferants (e.g., uric acid, ascorbic acid, norepinephrine, serotonin) will be rigorously tested, ensuring reliable performance for clinical and research applications. Supervision and Environment: The project will be supervised by Dr Rupam Das and Prof Monica Craciun, experts in biosensor technology and nanomaterials. The successful candidate will join a vibrant research community at the University of Exeter, benefiting from state-of-the-art facilities and interdisciplinary collaboration. Funding: A stipend of £20,780 per year is available for the duration of the PhD. Eligibility: Applicants should have a strong background in biomedical engineering, materials science, chemistry, electrical engineering, or a related field. Experience with nanomaterials, biosensors, or wireless electronics is advantageous. English language proficiency is required for non-native speakers. Application Process: Apply online via the University of Exeter portal using the provided link. For project-specific enquiries, contact Dr Rupam Das ([email protected]) or Prof Monica Craciun ([email protected]). The application deadline is 12 January 2025.