Sophie Hambleton

This postdoctoral research associate position at Newcastle University investigates the cellular drivers of type I interferon (IFN-I)-mediated neuropathology, with a focus on understanding the mechanisms underlying neurological diseases such as Alzheimer's and Parkinson's. IFN-I is recognized for its role in antiviral immunity, but its neurotoxic potential and involvement in neurodegenerative conditions are increasingly acknowledged. The project aims to clarify whether IFN-I contributes directly to CNS disease or is a consequence of neurological damage, addressing fundamental questions in the field. The research leverages a mouse model of type I interferonopathy associated with STAT2 mutation, previously identified by the group, to study pathological effects in various CNS cell types including microglia, neurones, and endothelial cells. Conditional in vivo expression of the pathogenic allele in specific cell types, combined with human induced pluripotent stem cell (hiPSC) models, will be used to dissect cellular mechanisms. The project also involves assessment of novel IFN-I inhibitors developed in collaboration with medicinal chemistry partners, providing a translational aspect to the research. The successful candidate will contribute to the development and execution of the project, determine appropriate methodologies, and participate in grant writing, publication, and dissemination of findings. The role includes opportunities for supervision of undergraduate and postgraduate students, engagement with support staff, and participation in public engagement activities. Applicants must have a PhD in immunology or neuroscience, with essential skills in innate antiviral immunity, advanced research techniques, and experience with stem cell or brain slice cultures. Desirable skills include in vivo model experience and bioinformatics analysis using R. The position is funded by the UK Medical Research Council, offering a competitive salary and excellent benefits, and is fixed term until July 2027. Newcastle University provides a supportive, inclusive, and diverse research environment, with a strong commitment to equality and career development. The Faculty of Medical Sciences is renowned for its research-led medical education and collaborative opportunities. Interested candidates should apply via the university portal and may contact Dr Christopher Duncan or Prof Sophie Hambleton for informal enquiries.