Fully Funded PhD: Mapping Rhythms of Health—Salt-dependent Regulation of Aldosterone Secretion by ACTH and Angiotensin II (ENDOTRAIN MSCA Doctoral Network)

This fully funded PhD position at the University of Bristol is part of the ENDOTRAIN MSCA Doctoral Network, focusing on the salt-dependent regulation of aldosterone secretion by ACTH and angiotensin II. The project aims to map the rhythms of health by investigating how sodium intake and daily activities influence aldosterone secretion in healthy individuals. High blood pressure is a major global health concern, and aldosterone is a key but under-recognised contributor. Understanding its dynamic regulation is crucial for improving diagnosis and treatment of disorders such as primary aldosteronism. As a doctoral candidate, you will design and conduct a clinical study with healthy volunteers, utilising innovative 24-hour dynamic hormone profiling (U-RHYTHM technology), wearable sensors, and patient questionnaires. The project involves integrating and analysing complex hormonal and physiological datasets, collaborating with mathematical modellers, and disseminating findings through publications and international conferences. You will also have the opportunity for a secondment at Ludwig-Maximilians-Universität München, working with leading experts in primary aldosteronism. The University of Bristol, ranked 51st globally and 8th in the UK (QS World University Rankings 2026), offers a vibrant academic environment and comprehensive support for international students. The ENDOTRAIN network provides interdisciplinary training, including workshops, retreats, transferable skills courses, and cohort-wide meetings across Europe. Applicants should hold a Master’s degree or equivalent in Medicine, Biomedicine, Physiology, Biotechnology, or a closely related field. Clinically trained candidates (MBChB or equivalent) are encouraged to apply. Strong interest in endocrinology, physiology, and data analysis, excellent English communication skills, and teamwork abilities are essential. Prior experience in clinical research or data science is advantageous. Eligibility requires that candidates have not resided or carried out their main activity in the UK for more than 12 months in the 36 months before recruitment. The position includes a 3-year full-time employment contract funded by the Marie Skłodowska-Curie Actions, covering tuition fees, training support, travel, and secondments. Applications must be submitted via the Jobbnorge portal with all mandatory attachments. The application deadline is February 15, 2026, and the latest start date is August 2026. For more information about the University and living in Bristol, visit the provided links. The programme encourages applications from minority and under-represented backgrounds and those who have faced challenges or disadvantages.