Uppsala University is offering one PhD and one postdoctoral position in the field of RNA structural biology, dynamics, and biophysics, with a focus on understanding RNA regulation in living cells. The research is based at the Department of Medical Biochemistry and Microbiology (IMBIM) and the Excellence Centre for the Chemical Mechanisms of Life, providing a vibrant international environment for interdisciplinary research and education.

The PhD project, supervised by Professor Katja Petzold, centers on the structural dynamics and regulation of RNA in cellular contexts. The research group investigates how RNA molecules adopt multiple conformational states and how these transitions are regulated within cells, impacting gene expression. The project employs advanced techniques such as RNA structural probing (SHAPE-MaP, DMS-MaP, RABS), NMR spectroscopy (including in-cell and solution NMR), computational modeling, and various biophysical and biochemical methods to study RNA-protein and RNA-ligand interactions. Functional analyses span diverse biological systems, including microRNAs, ribosomal RNA elements, and viral RNA motifs.

The postdoctoral position is part of the Excellence Centre for the Chemical Mechanisms of Life, a multidisciplinary initiative funded by the Swedish Research Council. The postdoc will work within the Petzold group and collaborate with other research leaders, focusing on RNA biophysics and structure under biologically relevant conditions. The role involves high-level research, method development, and active participation in the center's collaborative projects, including seminars and interdisciplinary activities.

Applicants for the PhD position should hold a master's degree in chemistry, biochemistry, molecular biology, biophysics, structural biology, or a related field, with a strong focus on RNA. Laboratory experience with biomolecules or RNA molecular biology is required, along with excellent English skills, independence, creativity, and teamwork. Programming, advanced data analysis, and experience with NGS, structural biology, or biophysical methods are advantageous. The postdoc position requires a PhD in natural or technical sciences, with expertise in RNA biophysics, biochemistry, and/or NMR. Additional merits include RNA sample preparation, cell handling, data/statistics/programming, pathway analysis, and scientific writing. IELTS/TOEFL results are desirable but not mandatory.

Both positions are fully funded, with the PhD appointment offering a full-time, fixed-term contract and salary according to local agreements, and the postdoc position providing a two-year, full-time contract with individual salary setting. Employment includes social benefits and access to university resources.

To apply, candidates should submit their application via the Uppsala University recruitment system, including a CV, cover letter, degree certificates, transcripts, a scientific/technical text, publications, and contact details for two referees. PhD applicants should also include reflections on the use of AI/LLM in research. The application deadlines are February 20, 2026, for the PhD position and February 23, 2026, for the postdoc position.

For further information, contact Professor Katja Petzold at [email protected]. Uppsala University is recognized for its strong international standing and commitment to high-quality research and education.