Uppsala University is offering a PhD position in Cellular RNA Structural Biology and Biophysics at the Department of Medical Biochemistry and Microbiology (IMBIM). The research focuses on the structure, dynamics, and function of RNA molecules in cells, with strong links to structural biology and molecular biophysics. The project, led by Professor Katja Petzold, aims to understand how RNA structures change in cells, what triggers these transitions, and the molecular mechanisms by which RNA dynamics regulate gene expression.

The doctoral student will use advanced techniques such as RNA structural probing (SHAPE-MaP, DMS-MaP, RABS), NMR spectroscopy (including in-cell and solution NMR), computational modeling, and various biophysical and biochemical methods to study RNA-protein and RNA-ligand interactions. Functional analyses will be performed in different cellular systems, including viruses, bacteria, and human cells. The research environment is highly international and collaborative, with opportunities to work on regulatory microRNAs, ribosomal RNA elements, or viral RNA motifs depending on the candidate's interests and expertise.

Applicants must hold an advanced degree in chemistry, biochemistry, molecular biology, biophysics, structural biology, or a related field, with a focus on RNA. Laboratory experience with biomolecules, nucleic acid biochemistry, or RNA molecular biology is required. Additional merits include programming/data analysis skills, experience with NGS data, structural biology or biophysical methods, and a strong interest in RNA structure and quantitative modeling. Excellent English communication skills, creativity, and the ability to work independently and collaboratively are essential.

The position is a full-time, fixed-term doctoral employment with salary according to local agreements. The application deadline is 20 February 2026. Applications must be submitted via the Uppsala University recruitment system and include a CV, personal statement, reflections on AI/LLM in research, thesis or scientific text, publications, transcripts, and contact details for two referees. For more information, contact Professor Katja Petzold at [email protected].