Biophysical Studies of Lipid-Protein Interactions

This PhD project at the University of Birmingham focuses on biophysical studies of lipid-protein interactions, aiming to deepen our understanding of cell membrane structure and the complex interplay between its components. The research investigates the diversity of lipid composition in bacterial, mammalian, and fungal membranes, seeking to elucidate the specific interactions that govern membrane properties and function. Using a combination of structural, spectroscopic, and electrochemical techniques, the project will analyze how surface charge and lipid headgroup structure influence peptide interactions with model membranes. These insights have practical applications in screening compounds to combat infections in humans, animals, and plants, potentially reducing the need for animal testing and contributing to crop and animal protection. A key methodological innovation is the use of Styrene Maleic Acid-based polymers to extract stabilized membrane proteins, forming SMALP particles that preserve proteins in their native lipid environment. The project will further develop this technology, employing advanced biophysical methods to study polymer interactions with membrane proteins and peptides, with the goal of predicting protein functionality within SMALPs. The outcomes are expected to expand the utility of SMALP technology in both academic and commercial settings. The studentship is funded by the BBSRC through the Midlands Integrated Biosciences Training Partnership (MIBTP), involving collaboration with several partner universities. Applicants should have a strong background in biochemistry, chemistry, physics, or related fields, and an interest in biophysical research. The application deadline is November 27, 2025, and candidates must apply via the dedicated MIBTP online portal.