PhD Position in Molecular Biology: Proteomics and Cancer Research at Radboud University
Radboud University is offering a fully funded PhD position in Molecular Biology, focusing on proteomics and cancer research within the renowned Vermeulen Lab at the Faculty of Science. This project is part of the Oncode Accelerator Growth Fund initiative, aiming to accelerate the development of new cancer therapies by investigating protein regulatory networks and their role in oncogenic signalling and disease progression.
As a PhD candidate, you will develop and apply innovative omics strategies to study protein–protein interactions and dynamic protein states, which are crucial for cellular identity and tumour biology. The research will employ advanced proteomic tools and workflows, including mass spectrometry, spatial proteomic profiling, and single-cell proteomics, to analyze primary cancer tissues, organoids, and clinical samples. A significant aspect of the project involves optimizing proteomic workflows for highly limited and heterogeneous samples, enabling in-depth profiling of tumour biology and establishing intratumoral heterogeneity maps using laser capture microdissection.
You will collaborate closely with a postdoctoral researcher to develop and implement novel proximity-labelling strategies, charting dynamic protein–protein interactions and local proteome environments. These methodological advancements will contribute to large-scale interaction and signalling network analyses across clinically annotated cohorts, providing unprecedented insights into how cancer-specific protein interaction networks are rewired in human disease. The findings are expected to inform new hypotheses on epigenetic control in cancer and support the translational goals of identifying actionable molecular targets for drug development.
The Vermeulen Lab is internationally recognized for its expertise in state-of-the-art proteomics technologies and offers a dynamic, interdisciplinary research environment. As part of the Oncode Accelerator consortium, you will collaborate with affiliated groups across the Netherlands and have access to clinical material and expertise in translational cancer research, as well as opportunities to connect with pharmaceutical companies.
Employment conditions include a temporary contract (1.0 FTE) for 1.5 years, extendable by 2.5 years upon positive evaluation. The starting salary is €3,059 gross per month, increasing to €3,881 in the fourth year, with additional benefits such as an 8% holiday allowance, 8.3% end-of-year bonus, extra annual leave (30 or 41 days), pension plan, and discounts on sports and cultural activities. Radboud University provides a supportive and inclusive work environment, with flexible working hours, training and development opportunities, and dual career coaching for partners.
Applicants must hold a Master’s degree in Molecular Biology, Biochemistry, Biomedical Sciences, or a related field, with a strong interest in mass spectrometry-based proteomics, cancer biology, and gene regulation. Hands-on experience with mammalian cell culture and molecular cloning is required, and prior experience with mass spectrometry-based techniques is advantageous. Candidates should possess analytical thinking skills, a collaborative mindset, and motivation to work in an interdisciplinary setting.
To apply, submit your application via the provided online link, addressing your letter to Prof. Michiel Vermeulen. Ensure all required documents are included as specified in the application form. The application deadline is 4 January 2026, with interviews scheduled to begin on 23 January. For further information, contact Prof. Michiel Vermeulen at [email protected].