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University of Bristol

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Funded PhD in Overcoming β-lactamase-Mediated Antibiotic Resistance through Biomolecular Simulation and Experiment University of Bristol in United Kingdom

Degree Level

PhD

Field of study

Biochemistry

Funding

Funded PhD studentship through the GW4 BioMed3 MRC Doctoral Landscape Programme. Funding includes UK tuition fees and a Doctoral Stipend matching the UK Research Council National Minimum (£21,805 p.a. for 2026/27, updated annually). Additional research training and support funding of up to £5,000 per annum is available.

Deadline

Oct 21, 2026

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Country

United Kingdom

University

University of Bristol

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Keywords

Biochemistry
Computer Science
Molecular Biology
Chemistry
Biomedical Engineering
Biology
Crystallography
Computational Chemistry
Molecular Dynamics
Antibiotic Resistance
Medical Science

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About this position

Funded PhD project at the University of Bristol in the School of Biochemistry and Biomedical Sciences, focused on β-lactamase-mediated antibiotic resistance, biomolecular simulation, enzyme kinetics, and X-ray crystallography.

The project investigates how class C β-lactamases break down cephalosporin antibiotics and how diazabicyclooctanone (DBO) inhibitors block these enzymes. The research combines computational chemistry, structural biology, molecular biology/biochemistry, and kinetic experiments to understand resistance mechanisms and predict new resistance-conferring variants.

Training includes cutting-edge computational and experimental methods, AI structure prediction, steady-state and stopped-/quenched-flow kinetics, bacterial killing assays, and access to Bristol/GW4 high-performance computing and X-ray facilities.

This is a funded PhD for students worldwide. Funding covers UK tuition fees plus a doctoral stipend matching the UK Research Council National Minimum (£21,805 p.a. for 2026/27), with up to £5,000 per year additional research training/support funding.

Apply through the GW4 BioMed website by 2026-10-21 5:00pm. You may select up to two projects and submit one application per candidate. Shortlisted applicants will be interviewed virtually in late January 2027, and the studentship starts on 2027-10-01.

Funding details

Funded PhD studentship through the GW4 BioMed3 MRC Doctoral Landscape Programme. Funding includes UK tuition fees and a Doctoral Stipend matching the UK Research Council National Minimum (£21,805 p.a. for 2026/27, updated annually). Additional research training and support funding of up to £5,000 per annum is available.

What's required

Applicants should be interested in multidisciplinary research spanning computational chemistry, molecular biology, biochemistry, enzyme kinetics, and structural biology. The project is suitable for students worldwide. The post does not specify a required prior degree, GPA, or language-test waiver in the text provided.

How to apply

Apply via the GW4 BioMed website and submit one application per candidate, selecting up to two projects. Complete the online application form linked from the GW4 BioMed website by 5:00pm on 2026-10-21. If shortlisted, attend a virtual interview on 2027-01-26 or 2027-01-27.

More information can be found here

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