University of Melbourne
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4 days ago
Honours project in neuroscience: generating neurons responsible for REM Sleep Behaviour Disorder from human pluripotent stem cells University of Melbourne in Australia
Degree Level
not provided
Field of study
Biology
Funding
Available scholarships are mentioned, and applicants are automatically considered for a range of scholarships; some other scholarships require a standalone application. No specific stipend, tuition, or funding amount is stated.
Country
Australia
University
University of Melbourne
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About this position
Research Degree Opportunity at the University of Melbourne / Florey Department of Neuroscience and Mental Health, Faculty of Medicine, Dentistry and Health Sciences.
This Honours project focuses on neuroscience, stem cell culture, neural differentiation, alpha-synuclein, RNA sequencing, and disease modelling for REM Sleep Behaviour Disorder (RBD). RBD is described as highly predictive of later Parkinson’s disease diagnosis and is considered a synucleinopathy. The project aims to generate and enrich the neurons responsible for RBD from human pluripotent stem cells, using a reporter line specific to the affected cell type.
Students will work with fibroblast samples from established RBD patients and healthy controls, convert them into pluripotent stem cells, and differentiate them into neural cells. The project also includes investigating the susceptibility of these patient-derived neurons to alpha-synuclein-induced degeneration. Major techniques mentioned include stem cell culture, neural differentiation, immunocytochemistry, RNA sequencing, and analysis.
Degree available: Honours.
Supervision: Carlos Gantner, Principal Supervisor, Florey Department of Neuroscience and Mental Health, University of Melbourne.
Funding: Applicants are automatically considered for a range of scholarships, though some scholarships require a separate application. No specific stipend or tuition details are provided.
Location: Florey Institute of Neuroscience & Mental Health, Melbourne, Australia.
How to apply: Submit an Expression of Interest via the project page. Check the scholarship information linked on the listing for additional funding opportunities.
Funding details
Available scholarships are mentioned, and applicants are automatically considered for a range of scholarships; some other scholarships require a standalone application. No specific stipend, tuition, or funding amount is stated.
What's required
Applicants should be interested in neuroscience and stem cell-based disease modelling. The project involves stem cell culture and neural differentiation, immunocytochemistry, RNA sequencing and analysis, and work with fibroblast-derived pluripotent stem cells. The listing is for an Honours research degree opportunity.
How to apply
Submit an Expression of Interest through the project page. Review the scholarship information linked on the listing if you want to be considered for additional funding opportunities.
More information can be found here
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